{"entity":{"id":"senescent-cells","kind":"term","name":"Hallmark (2022): senescent cells","aka":[],"tldr":"Cells that have permanently stopped dividing but stay alive and secrete inflammatory signals, helping nearby cancer cells grow and resist treatment.","summary":"Senescent cells, a hallmark added in 2022, are cells that have permanently stopped dividing but stay alive and secrete inflammatory signals, helping nearby cancer cells grow and resist treatment. The senescence-associated secretory phenotype arises from both stromal and tumour cells after therapy, and the underlying biology is laid out in the Cellular senescence pathway. Senolytic drugs aim to clear these cells in a one-two punch after cancer treatment, the strategy explored in the idea One-two punch: clear senescent cells after chemotherapy. Readers meet this hallmark from the Hallmarks of Cancer overview and from the 2022 hallmarks paper that added phenotypic plasticity, epigenetic reprogramming, microbiomes and senescent cells to the framework.","asOf":"2026-09-08","wikipedia":"https://en.wikipedia.org/wiki/Cellular_senescence","links":[{"label":"Hanahan, Hallmarks of Cancer: New Dimensions (Cancer Discovery 2022)","url":"https://doi.org/10.1158/2159-8290.CD-21-1059"}],"tags":["hallmark"],"related":[],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":["senescence"],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"category":"Cancer biology"},"route":"/terms/senescent-cells/","neighbours":{"pathway":[{"id":"senescence","kind":"pathway","name":"Cellular senescence","route":"/pathways/senescence/"}],"term":[{"id":"ageing-tissue-field-theory","kind":"term","name":"Ageing tissue and clonal fields: cancer as a disease of old tissue","route":"/terms/ageing-tissue-field-theory/"},{"id":"hallmarks-of-cancer","kind":"term","name":"Hallmarks of Cancer","route":"/terms/hallmarks-of-cancer/"},{"id":"hallmarks-synthesis","kind":"term","name":"Hallmarks of cancer as a synthesis of the theories","route":"/terms/hallmarks-synthesis/"}],"idea":[{"id":"idea-senolytics-after-chemo","kind":"idea","name":"One-two punch: clear senescent cells after chemotherapy","route":"/ideas/idea-senolytics-after-chemo/"}],"paper":[{"id":"paper-hallmarks-new-dimensions-cancer-discov-2022","kind":"paper","name":"Hallmarks of Cancer 2022: adding phenotypic plasticity, epigenetic reprogramming, microbiomes and senescent cells","route":"/key-papers/paper-hallmarks-new-dimensions-cancer-discov-2022/"}],"technology":[{"id":"rejuv-age-senescent-cells-after-treatment","kind":"technology","name":"Senescent cells and p16 after chemotherapy","route":"/technologies/rejuv-age-senescent-cells-after-treatment/"},{"id":"rejuv-frontier-senolytics","kind":"technology","name":"Senolytics after cancer treatment","route":"/technologies/rejuv-frontier-senolytics/"}]}}