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Cancers mutate faster than normal cells because their DNA repair and chromosome segregation are broken. This fuels every other hallmark.
Genome instability and mutation is the enabling characteristic that lets cancers mutate faster than normal cells because DNA repair and chromosome segregation are broken, fuelling every other hallmark. Its forms are defective mismatch repair (MSI), homologous recombination deficiency (BRCA and HRD), replication stress and chromosomal instability, covered in the DNA damage response, DNA replication stress and Chromosomal instability & aneuploidy pathways and the Whole-genome doubling (WGD) entry. It is exploited by PARP inhibitors guided by HRD & BRCA testing, by platinum, by immunotherapy for MSI-H and TMB-high tumours and by emerging CIN-directed drugs, with BRCA1 / BRCA2, PARP, ATR and TP53 as targets. Readers reach it from the Hallmarks of Cancer overview and the mutagenesis pathway.
In plain words · DNA repair genes. Inheriting a broken copy raises breast and ovarian cancer risk, but tumours that lose them become uniquely vulnerable to PARP inhibitors and platinum.
Showing the target this term concerns: BRCA1 / BRCA2 (HRD).
Shares The Hallmarks of Cancer: six capabilities every tumour must acquire, Hallmarks of Cancer, Hallmarks of cancer as a synthesis of the theories, TP53 and the tag hallmark.
Shares The Hallmarks of Cancer: six capabilities every tumour must acquire, Hallmarks of Cancer, Hallmarks of cancer as a synthesis of the theories, TP53 and the tag hallmark.
Shares The Hallmarks of Cancer: six capabilities every tumour must acquire, Hallmarks of Cancer, Hallmarks of cancer as a synthesis of the theories and the tag hallmark.
Shares The Hallmarks of Cancer: six capabilities every tumour must acquire, Hallmarks of Cancer and the tag hallmark.
Shares The Hallmarks of Cancer: six capabilities every tumour must acquire, Hallmarks of Cancer, Hallmarks of cancer as a synthesis of the theories and the tag hallmark.
Shares Hallmarks of Cancer, Hallmarks of cancer as a synthesis of the theories and the tag hallmark.
Shares The Hallmarks of Cancer: six capabilities every tumour must acquire, Hallmarks of Cancer, Hallmarks of cancer as a synthesis of the theories and the tag hallmark.
Shares Hallmarks of Cancer, Hallmarks of cancer as a synthesis of the theories and the tag hallmark.