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PPP6C (Serine/threonine-protein phosphatase 6 catalytic subunit) is an enzyme. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Skin cancer, Melanoma and Basal cell carcinoma.
Catalytic subunit of protein phosphatase 6 (PP6). PP6 is a component of a signalling pathway regulating cell cycle progression in response to IL2 receptor stimulation. N-terminal domain restricts G1 to S phase progression in cancer cells, in part through control of cyclin D1.
Open Targets scores its association with cancer at 0.70 (direct and indirect evidence; datatypes literature 0.84, genetic association 0.00, somatic mutation 0.91). IntOGen calls it a driver in 5 cohorts (3 activating, 2 loss-of-function), covering Basal Cell Carcinoma, Melanoma, Cutaneous Melanoma.
In plain words · PPP6C (Serine/threonine-protein phosphatase 6 catalytic subunit) is an enzyme. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Skin cancer, Melanoma and Basal cell carcinoma.
PPP6C (Serine/threonine-protein phosphatase 6 catalytic subunit) is an enzyme. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Skin cancer, Melanoma and Basal cell carcinoma.
Catalytic subunit of protein phosphatase 6 (PP6). PP6 is a component of a signalling pathway regulating cell cycle progression in response to IL2 receptor stimulation.
No product in this corpus aims at PPP6C yet. Inhibitors are shaped to fit the enzyme's active site so the reaction the cancer relies on stops.
First described 1996. Earliest sequence paper UniProt cites for the protein: Bastians et al, J. Cell Sci, 1996, "The novel human protein serine/threonine phosphatase 6 is a functional homologue of budding yeast Sit4p and fission yeast ppe1, which are involved in cell cycle regulation". Source.
Sources: HGNC HGNC:9323 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt O00743 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000119414 (association with cancer (MONDO_0004992) 0.70; per-cancer scores at or above 0.5: melanoma 0.70, skin cancer 0.64 (GraphQL API, CC0)); IntOGen PPP6C (driver in 5 cohorts (Act 3, LoF 2); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Catalytic subunit of protein phosphatase 6 (PP6). PP6 is a component of a signalling pathway regulating cell cycle progression in response to IL2 receptor stimulation. N-terminal domain restricts G1 to S phase progression in cancer cells, in part through control of cyclin D1. During mitosis, regulates spindle positioning. Down-regulates MAP3K7 kinase activation of the IL1 signalling pathway by dephosphorylation of MAP3K7. Also participates in the innate immune defense against viruses by desphosphorylating RIGI, an essential step that triggers RIGI-mediated signalling activation. Location: Mitochondrion; Cytoplasm (UniProt). Locus 9q33.3 (HGNC).
Query for this target: (TITLE:"PPP6C" OR ABSTRACT:"PPP6C" OR TITLE:"protein phosphatase 6 catalytic subunit" OR ABSTRACT:"protein phosphatase 6 catalytic subunit" OR TITLE:"Serine/threonine-protein phosphatase 6 catalytic subunit" OR ABSTRACT:"Serine/threonine-protein phosphatase 6 catalytic subunit" OR TITLE:"PP6" OR ABSTRACT:"PP6") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about PPP6C, not a curated reading list.
Shares Basal cell carcinoma, Skin cancer (all types), Melanoma, Open Targets Platform.
Shares Basal cell carcinoma, Skin cancer (all types), Melanoma, Open Targets Platform.
Shares Basal cell carcinoma, Skin cancer (all types), Melanoma, Open Targets Platform.
Shares Basal cell carcinoma, Skin cancer (all types), Open Targets Platform.
Shares Basal cell carcinoma, Skin cancer (all types), Open Targets Platform.
Shares Basal cell carcinoma, Skin cancer (all types), Open Targets Platform.
Shares Basal cell carcinoma, Skin cancer (all types), Open Targets Platform.
Shares Basal cell carcinoma, Skin cancer (all types), Open Targets Platform.