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KRT5 (Keratin, type II cytoskeletal 5) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Skin cancer and Basal cell carcinoma.
Structural component of intermediate filaments in basal keratinocytes of stratified epithelia. Forms heteropolymers with type I partners including KRT14 and KRT15, contributing to the formation of the keratin intermediate filament network that provides mechanical stability and resilience to the basal layer of the epidermis. Regulates the recruitment of Langerhans cells to the epidermis, potentially by modulation of the abundance of macrophage chemotactic cytokines, macrophage inflammatory cytokines and CTNND1 localisation in keratinocytes.
Open Targets scores its association with cancer at 0.59 (direct and indirect evidence; datatypes literature 0.98, animal model 0.42, genetic association 0.73).
In plain words · KRT5 (Keratin, type II cytoskeletal 5) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Skin cancer and Basal cell carcinoma.
KRT5 (Keratin, type II cytoskeletal 5) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Skin cancer and Basal cell carcinoma.
Structural component of intermediate filaments in basal keratinocytes of stratified epithelia.
No product in this corpus aims at KRT5 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
First described 1988. Earliest sequence paper UniProt cites for the protein: Eckert R.L. et al, DNA, 1988, "The sequence of the human epidermal 58-kD (#5) type II keratin reveals an absence of 5' upstream sequence conservation between coexpressed epidermal keratins". Source.
Sources: HGNC HGNC:6442 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P13647 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000186081 (association with cancer (MONDO_0004992) 0.59; per-cancer scores at or above 0.5: skin cancer 0.56, basal cell carcinoma 0.56 (GraphQL API, CC0))
Structural component of intermediate filaments in basal keratinocytes of stratified epithelia. Forms heteropolymers with type I partners including KRT14 and KRT15, contributing to the formation of the keratin intermediate filament network that provides mechanical stability and resilience to the basal layer of the epidermis. Regulates the recruitment of Langerhans cells to the epidermis, potentially by modulation of the abundance of macrophage chemotactic cytokines, macrophage inflammatory cytokines and CTNND1 localisation in keratinocytes. Location: Cytoplasm (UniProt). Locus 12q13.13 (HGNC).
Query for this target: (TITLE:"KRT5" OR ABSTRACT:"KRT5" OR TITLE:"keratin 5" OR ABSTRACT:"keratin 5" OR TITLE:"Keratin, type II cytoskeletal 5" OR ABSTRACT:"Keratin, type II cytoskeletal 5" OR TITLE:"KRT5A" OR ABSTRACT:"KRT5A" OR TITLE:"CK-5" OR ABSTRACT:"CK-5" OR TITLE:"EBS2" OR ABSTRACT:"EBS2") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about KRT5, not a curated reading list.
Shares Basal cell carcinoma, Skin cancer (all types), Open Targets Platform.
Shares Basal cell carcinoma, Skin cancer (all types), Open Targets Platform.
Shares Basal cell carcinoma, Skin cancer (all types), Open Targets Platform.
Shares Basal cell carcinoma, Skin cancer (all types), Open Targets Platform.
Shares Basal cell carcinoma, Skin cancer (all types), Open Targets Platform.
Shares Basal cell carcinoma, Skin cancer (all types), Open Targets Platform.
Shares Basal cell carcinoma, Skin cancer (all types), Open Targets Platform.
Shares Basal cell carcinoma, Skin cancer (all types), Open Targets Platform.