Loading
CPVL (Probable serine carboxypeptidase CPVL) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role. Tied to Skin cancer and Basal cell carcinoma.
May be involved in the digestion of phagocytosed particles in the lysosome, participation in an inflammatory protease cascade, and trimming of peptides for antigen presentation.
Open Targets scores its association with cancer at 0.61 (direct and indirect evidence; datatypes literature 0.86, animal model 0.57, genetic association 0.75).
In plain words · CPVL (Probable serine carboxypeptidase CPVL) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role. Tied to Skin cancer and Basal cell carcinoma.
CPVL (Probable serine carboxypeptidase CPVL) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role. Tied to Skin cancer and Basal cell carcinoma.
May be involved in the digestion of phagocytosed particles in the lysosome, participation in an inflammatory protease cascade, and trimming of peptides for antigen presentation. Locus 7p14.3 (HGNC).
No product in this corpus aims at CPVL yet. Inhibitors are shaped to fit the enzyme's active site so the reaction the cancer relies on stops.
First described 2000. Earliest sequence paper UniProt cites for the protein: Cho J.-J. et al, 2000, "Cloning of VCP-like protein expressed in human heart and placenta". Source.
Sources: HGNC HGNC:14399 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9H3G5 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000106066 (association with cancer (MONDO_0004992) 0.61; per-cancer scores at or above 0.5: skin cancer 0.57, basal cell carcinoma 0.55 (GraphQL API, CC0))
May be involved in the digestion of phagocytosed particles in the lysosome, participation in an inflammatory protease cascade, and trimming of peptides for antigen presentation. Locus 7p14.3 (HGNC).
Query for this target: (TITLE:"CPVL" OR ABSTRACT:"CPVL" OR TITLE:"carboxypeptidase vitellogenic like" OR ABSTRACT:"carboxypeptidase vitellogenic like" OR TITLE:"Probable serine carboxypeptidase CPVL" OR ABSTRACT:"Probable serine carboxypeptidase CPVL") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about CPVL, not a curated reading list.
Shares Basal cell carcinoma, Skin cancer (all types), Open Targets Platform.
Shares Basal cell carcinoma, Skin cancer (all types), Open Targets Platform.
Shares Basal cell carcinoma, Skin cancer (all types), Open Targets Platform.
Shares Basal cell carcinoma, Skin cancer (all types), Open Targets Platform.
Shares Basal cell carcinoma, Skin cancer (all types), Open Targets Platform.
Shares Basal cell carcinoma, Skin cancer (all types), Open Targets Platform.
Shares Basal cell carcinoma, Skin cancer (all types), Open Targets Platform.
Shares Basal cell carcinoma, Skin cancer (all types), Open Targets Platform.