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SLC45A2 (Membrane-associated transporter protein) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Skin cancer, Melanoma and Basal cell carcinoma.
Proton-associated glucose and sucrose transporter. May be able to transport also fructose. Expressed at a late melanosome maturation stage where functions as proton/glucose exporter which increase lumenal pH by decreasing glycolysis.
Open Targets scores its association with cancer at 0.61 (direct and indirect evidence; datatypes literature 0.90, animal model 0.47, genetic association 0.71).
In plain words · SLC45A2 (Membrane-associated transporter protein) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Skin cancer, Melanoma and Basal cell carcinoma.
SLC45A2 (Membrane-associated transporter protein) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Skin cancer, Melanoma and Basal cell carcinoma.
Proton-associated glucose and sucrose transporter. May be able to transport also fructose.
No product in this corpus aims at SLC45A2 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
First described 2001. Earliest sequence paper UniProt cites for the protein: Harada et al, Cancer Res, 2001, "Use of an in vitro immunoselected tumor line to identify shared melanoma antigens recognized by HLA-A*0201-restricted T cells". Source.
Sources: HGNC HGNC:16472 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9UMX9 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000164175 (association with cancer (MONDO_0004992) 0.61; per-cancer scores at or above 0.5: melanoma 0.55, skin cancer 0.59, basal cell carcinoma 0.51 (GraphQL API, CC0))
Proton-associated glucose and sucrose transporter. May be able to transport also fructose. Expressed at a late melanosome maturation stage where functions as proton/glucose exporter which increase lumenal pH by decreasing glycolysis. Regulates melanogenesis by maintaining melanosome neutralisation that is initially initiated by transient OCA2 and required for a proper function of the tyrosinase TYR. Location: Melanosome membrane (UniProt). Locus 5p13.2 (HGNC).
Query for this target: (TITLE:"SLC45A2" OR ABSTRACT:"SLC45A2" OR TITLE:"solute carrier family 45 member 2" OR ABSTRACT:"solute carrier family 45 member 2" OR TITLE:"Membrane-associated transporter protein" OR ABSTRACT:"Membrane-associated transporter protein" OR TITLE:"AIM-1" OR ABSTRACT:"AIM-1" OR TITLE:"OCA4" OR ABSTRACT:"OCA4") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about SLC45A2, not a curated reading list.
Shares Basal cell carcinoma, Skin cancer (all types), Melanoma, Open Targets Platform.
Shares Basal cell carcinoma, Skin cancer (all types), Melanoma, Open Targets Platform.
Shares Basal cell carcinoma, Skin cancer (all types), Melanoma, Open Targets Platform.
Shares Basal cell carcinoma, Skin cancer (all types), Open Targets Platform.
Shares Basal cell carcinoma, Skin cancer (all types), Open Targets Platform.
Shares Basal cell carcinoma, Skin cancer (all types), Open Targets Platform.
Shares Basal cell carcinoma, Skin cancer (all types), Open Targets Platform.
Shares Basal cell carcinoma, Skin cancer (all types), Open Targets Platform.