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CTSS (Cathepsin S) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role. Tied to Skin cancer and Basal cell carcinoma.
Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules and MHC class II antigen presentation. The bond-specificity of this proteinase is in part similar to the specificities of cathepsin L.
Open Targets scores its association with cancer at 0.57 (direct and indirect evidence; datatypes literature 0.98, genetic association 0.71).
In plain words · CTSS (Cathepsin S) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role. Tied to Skin cancer and Basal cell carcinoma.
CTSS (Cathepsin S) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role. Tied to Skin cancer and Basal cell carcinoma.
Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules and MHC class II antigen presentation.
No product in this corpus aims at CTSS yet. Inhibitors are shaped to fit the enzyme's active site so the reaction the cancer relies on stops.
First described 1992. Earliest sequence paper UniProt cites for the protein: Shi G.-P. et al, J. Biol. Chem, 1992, "Molecular cloning and expression of human alveolar macrophage cathepsin S, an elastinolytic cysteine protease". Source.
Sources: HGNC HGNC:2545 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P25774 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000163131 (association with cancer (MONDO_0004992) 0.57; per-cancer scores at or above 0.5: skin cancer 0.50, basal cell carcinoma 0.52 (GraphQL API, CC0))
Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules and MHC class II antigen presentation. The bond-specificity of this proteinase is in part similar to the specificities of cathepsin L. Elicits itch by mediating cleavage and activation of MRGPRX1. Location: Lysosome; Secreted; Cytoplasmic vesicle, phagosome (UniProt). Locus 1q21.3 (HGNC).
Query for this target: (TITLE:"CTSS" OR ABSTRACT:"CTSS" OR TITLE:"cathepsin S" OR ABSTRACT:"cathepsin S" OR TITLE:"Cathepsin S" OR ABSTRACT:"Cathepsin S") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about CTSS, not a curated reading list.
Shares Basal cell carcinoma, Skin cancer (all types), Open Targets Platform.
Shares Basal cell carcinoma, Skin cancer (all types), Open Targets Platform.
Shares Basal cell carcinoma, Skin cancer (all types), Open Targets Platform.
Shares Basal cell carcinoma, Skin cancer (all types), Open Targets Platform.
Shares Basal cell carcinoma, Skin cancer (all types), Open Targets Platform.
Shares Basal cell carcinoma, Skin cancer (all types), Open Targets Platform.
Shares Basal cell carcinoma, Skin cancer (all types), Open Targets Platform.
Shares Basal cell carcinoma, Skin cancer (all types), Open Targets Platform.