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BNC2 (Zinc finger protein basonuclin-2) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role. Tied to Skin cancer and Basal cell carcinoma.
Probable transcription factor specific for skin keratinocytes. May play a role in the differentiation of spermatozoa and oocytes. May also play an important role in early urinary-tract development.
Open Targets scores its association with cancer at 0.57 (direct and indirect evidence; datatypes literature 0.87, animal model 0.45, genetic association 0.71).
In plain words · BNC2 (Zinc finger protein basonuclin-2) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role. Tied to Skin cancer and Basal cell carcinoma.
BNC2 (Zinc finger protein basonuclin-2) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role. Tied to Skin cancer and Basal cell carcinoma.
Probable transcription factor specific for skin keratinocytes. May play a role in the differentiation of spermatozoa and oocytes.
No product in this corpus aims at BNC2 yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
First described 2004. Earliest sequence paper UniProt cites for the protein: Ota et al, Nat. Genet, 2004, "Complete sequencing and characterization of 21,243 full-length human cDNAs". Source.
Sources: HGNC HGNC:30988 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q6ZN30 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000173068 (association with cancer (MONDO_0004992) 0.57; per-cancer scores at or above 0.5: skin cancer 0.52, basal cell carcinoma 0.53 (GraphQL API, CC0))
Probable transcription factor specific for skin keratinocytes. May play a role in the differentiation of spermatozoa and oocytes. May also play an important role in early urinary-tract development. Location: Nucleus (UniProt). Locus 9p22.3-p22.2 (HGNC).
Query for this target: (TITLE:"BNC2" OR ABSTRACT:"BNC2" OR TITLE:"basonuclin zinc finger protein 2" OR ABSTRACT:"basonuclin zinc finger protein 2" OR TITLE:"Zinc finger protein basonuclin-2" OR ABSTRACT:"Zinc finger protein basonuclin-2" OR TITLE:"BSN2" OR ABSTRACT:"BSN2" OR TITLE:"FLJ20043" OR ABSTRACT:"FLJ20043" OR TITLE:"bn2" OR ABSTRACT:"bn2") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about BNC2, not a curated reading list.
Shares Basal cell carcinoma, Skin cancer (all types), Open Targets Platform.
Shares Basal cell carcinoma, Skin cancer (all types), Open Targets Platform.
Shares Basal cell carcinoma, Skin cancer (all types), Open Targets Platform.
Shares Basal cell carcinoma, Skin cancer (all types), Open Targets Platform.
Shares Basal cell carcinoma, Skin cancer (all types), Open Targets Platform.
Shares Basal cell carcinoma, Skin cancer (all types), Open Targets Platform.
Shares Basal cell carcinoma, Skin cancer (all types), Open Targets Platform.
Shares Basal cell carcinoma, Skin cancer (all types), Open Targets Platform.