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TYR (Tyrosinase) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role. Tied to Skin cancer, Melanoma and Basal cell carcinoma.
This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. Catalyses the initial and rate limiting step in the cascade of reactions leading to melanin production from tyrosine. In addition to hydroxylating tyrosine to DOPA (3,4-dihydroxyphenylalanine), also catalyses the oxidation of DOPA to DOPA-quinone, and possibly the oxidation of DHI (5,6-dihydroxyindole) to indole-5,6 quinone.
Open Targets scores its association with cancer at 0.59 (direct and indirect evidence; datatypes literature 0.59, animal model 0.58, genetic association 0.74).
In plain words · TYR (Tyrosinase) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role. Tied to Skin cancer, Melanoma and Basal cell carcinoma.
TYR (Tyrosinase) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role. Tied to Skin cancer, Melanoma and Basal cell carcinoma.
This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds.
No product in this corpus aims at TYR yet. Inhibitors are shaped to fit the enzyme's active site so the reaction the cancer relies on stops.
First described 1987. Earliest sequence paper UniProt cites for the protein: Kwon B.S. et al, Proc. Natl. Acad. Sci. U.S.A, 1987, "Isolation and sequence of a cDNA clone for human tyrosinase that maps at the mouse c-albino locus". Source.
Sources: HGNC HGNC:12442 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P14679 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000077498 (association with cancer (MONDO_0004992) 0.59; per-cancer scores at or above 0.5: melanoma 0.59, skin cancer 0.56, basal cell carcinoma 0.54 (GraphQL API, CC0))
This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. Catalyses the initial and rate limiting step in the cascade of reactions leading to melanin production from tyrosine. In addition to hydroxylating tyrosine to DOPA (3,4-dihydroxyphenylalanine), also catalyses the oxidation of DOPA to DOPA-quinone, and possibly the oxidation of DHI (5,6-dihydroxyindole) to indole-5,6 quinone. Location: Melanosome membrane; Melanosome (UniProt). Locus 11q14.3 (HGNC).
Query for this target: (TITLE:"TYR" OR ABSTRACT:"TYR" OR TITLE:"tyrosinase" OR ABSTRACT:"tyrosinase" OR TITLE:"Tyrosinase" OR ABSTRACT:"Tyrosinase" OR TITLE:"OCAIA" OR ABSTRACT:"OCAIA" OR TITLE:"OCA1A" OR ABSTRACT:"OCA1A" OR TITLE:"OCA1" OR ABSTRACT:"OCA1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about TYR, not a curated reading list.
Shares Basal cell carcinoma, Skin cancer (all types), Melanoma, Open Targets Platform.
Shares Basal cell carcinoma, Skin cancer (all types), Melanoma, Open Targets Platform.
Shares Basal cell carcinoma, Skin cancer (all types), Melanoma, Open Targets Platform.
Shares Basal cell carcinoma, Skin cancer (all types), Open Targets Platform.
Shares Basal cell carcinoma, Skin cancer (all types), Open Targets Platform.
Shares Basal cell carcinoma, Skin cancer (all types), Open Targets Platform.
Shares Basal cell carcinoma, Skin cancer (all types), Open Targets Platform.
Shares Basal cell carcinoma, Skin cancer (all types), Open Targets Platform.