Loading
TGM3 (Protein-glutamine gamma-glutamyltransferase E) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role. Tied to Skin cancer and Basal cell carcinoma.
Catalyses the calcium-dependent formation of isopeptide cross-links between glutamine and lysine residues in various proteins, as well as the conjugation of polyamines to proteins. Involved in the formation of the cornified envelope (CE), a specialised component consisting of covalent cross-links of proteins beneath the plasma membrane of terminally differentiated keratinocytes. Catalyses small proline-rich proteins (SPRR1 and SPRR2) and LOR cross-linking to form small interchain oligomers, which are further cross-linked by TGM1 onto the growing CE scaffold.
Open Targets scores its association with cancer at 0.57 (direct and indirect evidence; datatypes literature 0.91, animal model 0.70, genetic association 0.70).
In plain words · TGM3 (Protein-glutamine gamma-glutamyltransferase E) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role. Tied to Skin cancer and Basal cell carcinoma.
TGM3 (Protein-glutamine gamma-glutamyltransferase E) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role. Tied to Skin cancer and Basal cell carcinoma.
Catalyses the calcium-dependent formation of isopeptide cross-links between glutamine and lysine residues in various proteins, as well as the conjugation of polyamines to proteins.
No product in this corpus aims at TGM3 yet. Inhibitors are shaped to fit the enzyme's active site so the reaction the cancer relies on stops.
First described 1993. Earliest sequence paper UniProt cites for the protein: Kim I.-G. et al, J. Biol. Chem, 1993, "The deduced sequence of the novel protransglutaminase E (TGase3) of human and mouse". Source.
Sources: HGNC HGNC:11779 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q08188 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000125780 (association with cancer (MONDO_0004992) 0.57; per-cancer scores at or above 0.5: skin cancer 0.54, basal cell carcinoma 0.53 (GraphQL API, CC0))
Catalyses the calcium-dependent formation of isopeptide cross-links between glutamine and lysine residues in various proteins, as well as the conjugation of polyamines to proteins. Involved in the formation of the cornified envelope (CE), a specialised component consisting of covalent cross-links of proteins beneath the plasma membrane of terminally differentiated keratinocytes. Catalyses small proline-rich proteins (SPRR1 and SPRR2) and LOR cross-linking to form small interchain oligomers, which are further cross-linked by TGM1 onto the growing CE scaffold. In hair follicles, involved in cross-linking structural proteins to hardening the inner root sheath. Location: Cytoplasm (UniProt). Locus 20p13 (HGNC).
Query for this target: (TITLE:"TGM3" OR ABSTRACT:"TGM3" OR TITLE:"transglutaminase 3" OR ABSTRACT:"transglutaminase 3" OR TITLE:"Protein-glutamine gamma-glutamyltransferase E" OR ABSTRACT:"Protein-glutamine gamma-glutamyltransferase E") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about TGM3, not a curated reading list.
Shares Basal cell carcinoma, Skin cancer (all types), Open Targets Platform.
Shares Basal cell carcinoma, Skin cancer (all types), Open Targets Platform.
Shares Basal cell carcinoma, Skin cancer (all types), Open Targets Platform.
Shares Basal cell carcinoma, Skin cancer (all types), Open Targets Platform.
Shares Basal cell carcinoma, Skin cancer (all types), Open Targets Platform.
Shares Basal cell carcinoma, Skin cancer (all types), Open Targets Platform.
Shares Basal cell carcinoma, Skin cancer (all types), Open Targets Platform.
Shares Basal cell carcinoma, Skin cancer (all types), Open Targets Platform.