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NFIB (Nuclear factor 1 B-type) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role. Tied to Breast cancer, Oral cavity cancer and Adenoid cystic carcinoma.
Transcriptional activator of GFAP, essential for proper brain development. Recognises and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.
Open Targets scores its association with cancer at 0.67 (direct and indirect evidence; datatypes affected pathway 0.31, literature 0.98, genetic association 0.35, somatic mutation 0.94, animal model 0.85).
In plain words · NFIB (Nuclear factor 1 B-type) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role. Tied to Breast cancer, Oral cavity cancer and Adenoid cystic carcinoma.
NFIB (Nuclear factor 1 B-type) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role. Tied to Breast cancer, Oral cavity cancer and Adenoid cystic carcinoma.
Transcriptional activator of GFAP, essential for proper brain development. Recognises and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2.
No product in this corpus aims at NFIB yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
First described 1995. Earliest sequence paper UniProt cites for the protein: Qian et al, Genomics, 1995, "Chromosomal localization of the four genes (NFIA, B, C, and X) for the human transcription factor nuclear factor I by FISH". Source.
Sources: HGNC HGNC:7785 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt O00712 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000147862 (association with cancer (MONDO_0004992) 0.67; per-cancer scores at or above 0.5: breast cancer 0.52, oral cavity cancer 0.55, adenoid cystic carcinoma 0.52 (GraphQL API, CC0))
Transcriptional activator of GFAP, essential for proper brain development. Recognises and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. Location: Nucleus (UniProt). Locus 9p23-p22.3 (HGNC).
Query for this target: (TITLE:"NFIB" OR ABSTRACT:"NFIB" OR TITLE:"nuclear factor I B" OR ABSTRACT:"nuclear factor I B" OR TITLE:"Nuclear factor 1 B-type" OR ABSTRACT:"Nuclear factor 1 B-type" OR TITLE:"NFI-RED" OR ABSTRACT:"NFI-RED" OR TITLE:"NFIB2" OR ABSTRACT:"NFIB2" OR TITLE:"NFIB3" OR ABSTRACT:"NFIB3") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about NFIB, not a curated reading list.
Shares Oral cavity cancer (mouth and tongue), Breast cancer (all types), Open Targets Platform.
Shares Oral cavity cancer (mouth and tongue), Breast cancer (all types), Open Targets Platform.
Shares Oral cavity cancer (mouth and tongue), Breast cancer (all types), Open Targets Platform.
Shares Oral cavity cancer (mouth and tongue), Open Targets Platform.
Shares Oral cavity cancer (mouth and tongue), Open Targets Platform.
Shares Oral cavity cancer (mouth and tongue), Open Targets Platform.
Shares Adenoid cystic carcinoma, Oral cavity cancer (mouth and tongue), Open Targets Platform.
Shares Oral cavity cancer (mouth and tongue), Breast cancer (all types), Open Targets Platform.