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CRTC1 (CREB-regulated transcription coactivator 1) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Salivary gland cancers, Lung cancer, Skin cancer and 5 more.
Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signalling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4.
Open Targets scores its association with cancer at 0.67 (direct and indirect evidence; datatypes literature 0.82, animal model 0.26, genetic association 0.26, somatic mutation 0.84). IntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Adenoid Cystic Carcinoma.
In plain words · CRTC1 (CREB-regulated transcription coactivator 1) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Salivary gland cancers, Lung cancer, Skin cancer and 5 more.
CRTC1 (CREB-regulated transcription coactivator 1) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Salivary gland cancers, Lung cancer, Skin cancer and 5 more.
Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites.
No product in this corpus aims at CRTC1 yet. Drugs fit a pocket that exists only in one shape of the mutant protein and hold it there, off.
First described 1998. Earliest sequence paper UniProt cites for the protein: Ishikawa et al, DNA Res, 1998, "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". Source.
Sources: HGNC HGNC:16062 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q6UUV9 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000105662 (association with cancer (MONDO_0004992) 0.67; per-cancer scores at or above 0.5: non-small cell lung carcinoma 0.54, colorectal cancer 0.51, oesophageal cancer 0.51, skin cancer 0.51, lung cancer 0.56, oral cavity cancer 0.56 (GraphQL API, CC0)); IntOGen CRTC1 (driver in 1 cohort (Act 1, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signalling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PGC1alpha and inducer of mitochondrial biogenesis in muscle cells. In the hippocampus, involved in late-phase long-term potentiation (L-LTP) maintenance at the Schaffer collateral-CA1 synapses. Location: Cytoplasm; Nucleus (UniProt). Locus 19p13.11 (HGNC).
Query for this target: (TITLE:"CRTC1" OR ABSTRACT:"CRTC1" OR TITLE:"CREB regulated transcription coactivator 1" OR ABSTRACT:"CREB regulated transcription coactivator 1" OR TITLE:"CREB-regulated transcription coactivator 1" OR ABSTRACT:"CREB-regulated transcription coactivator 1" OR TITLE:"KIAA0616" OR ABSTRACT:"KIAA0616" OR TITLE:"FLJ14027" OR ABSTRACT:"FLJ14027" OR TITLE:"TORC1" OR ABSTRACT:"TORC1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about CRTC1, not a curated reading list.
Shares Mucoepidermoid carcinoma, Oral cavity cancer (mouth and tongue), Skin cancer (all types), IntOGen.
Shares Salivary gland cancers, Skin cancer (all types), IntOGen, Lung cancer (all types).
Shares Salivary gland cancers, Skin cancer (all types), IntOGen, Lung cancer (all types).
Shares Adenoid cystic carcinoma, Salivary gland cancers, IntOGen.
Shares Adenoid cystic carcinoma, Oral cavity cancer (mouth and tongue), Open Targets Platform.
Shares Oral cavity cancer (mouth and tongue), IntOGen, Open Targets Platform.