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TRRAP (Transformation/transcription domain-associated protein) is a protein that switches other genes on and off. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Bladder & urothelial cancer, Renal cell carcinoma, Lung cancer and 5 more.
Adapter protein, which is found in various multiprotein chromatin complexes with histone acetyltransferase activity (HAT), which gives a specific tag for epigenetic transcription activation. Component of the NuA4 histone acetyltransferase complex which is responsible for acetylation of nucleosomal histones H4 and H2A. Plays a central role in MYC transcription activation, and also participates in cell transformation by MYC.
Open Targets scores its association with cancer at 0.74 (direct and indirect evidence; datatypes literature 0.69, animal model 0.31, genetic association 0.00, somatic mutation 0.89). IntOGen calls it a driver in 14 cohorts (11 activating, 2 loss-of-function), covering Adenoid Cystic Carcinoma, Angiosarcoma, Bladder Urothelial Carcinoma, Renal Clear Cell Carcinoma, Cholangiocarcinoma, Head and Neck Squamous Cell Carcinoma and others.
In plain words · TRRAP (Transformation/transcription domain-associated protein) is a protein that switches other genes on and off. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Bladder & urothelial cancer, Renal cell carcinoma, Lung cancer and 5 more.
TRRAP (Transformation/transcription domain-associated protein) is a protein that switches other genes on and off. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Bladder & urothelial cancer, Renal cell carcinoma, Lung cancer and 5 more.
Adapter protein, which is found in various multiprotein chromatin complexes with histone acetyltransferase activity (HAT), which gives a specific tag for epigenetic transcription activation.
No product in this corpus aims at TRRAP yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
First described 1998. Earliest sequence paper UniProt cites for the protein: McMahon S.B. et al, Cell, 1998, "The novel ATM-related protein TRRAP is an essential cofactor for the c-Myc and E2F oncoproteins". Source.
Sources: HGNC HGNC:12347 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9Y4A5 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000196367 (association with cancer (MONDO_0004992) 0.74; per-cancer scores at or above 0.5: colorectal cancer 0.54, gastric cancer 0.52, urinary bladder cancer 0.55, ovarian cancer 0.51, melanoma 0.63, skin cancer 0.57 (GraphQL API, CC0)); IntOGen TRRAP (driver in 14 cohorts (Act 11, LoF 2); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Adapter protein, which is found in various multiprotein chromatin complexes with histone acetyltransferase activity (HAT), which gives a specific tag for epigenetic transcription activation. Component of the NuA4 histone acetyltransferase complex which is responsible for acetylation of nucleosomal histones H4 and H2A. Plays a central role in MYC transcription activation, and also participates in cell transformation by MYC. Required for p53/TP53-, E2F1- and E2F4-mediated transcription activation. Also involved in transcription activation mediated by the adenovirus E1A, a viral oncoprotein that deregulates transcription of key genes. Probably acts by linking transcription factors such as E1A, MYC or E2F1 to HAT complexes such as STAGA thereby allowing transcription activation. Location: Nucleus (UniProt). Locus 7q22.1 (HGNC).
Query for this target: (TITLE:"TRRAP" OR ABSTRACT:"TRRAP" OR TITLE:"transformation/transcription domain associated protein" OR ABSTRACT:"transformation/transcription domain associated protein" OR TITLE:"Transformation/transcription domain-associated protein" OR ABSTRACT:"Transformation/transcription domain-associated protein" OR TITLE:"TR-AP" OR ABSTRACT:"TR-AP" OR TITLE:"PAF400" OR ABSTRACT:"PAF400" OR TITLE:"Tra1" OR ABSTRACT:"Tra1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about TRRAP, not a curated reading list.
Shares Salivary gland cancers, Skin cancer (all types), IntOGen, Lung cancer (all types).
Shares Salivary gland cancers, Skin cancer (all types), IntOGen, Lung cancer (all types).
Shares Salivary gland cancers, Renal cell carcinoma, Skin cancer (all types), IntOGen.
Shares Salivary gland cancers, Skin cancer (all types), Bladder & urothelial cancer, IntOGen.
Shares Salivary gland cancers, IntOGen.
Shares Salivary gland cancers, IntOGen, Lung cancer (all types), Open Targets Platform.
Shares Salivary gland cancers, IntOGen.
Shares Salivary gland cancers, Head and neck squamous cell carcinoma.