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TYW2 (tRNA wybutosine-synthesising protein 2 homolog) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Salivary gland cancers.
S-adenosyl-L-methionine-dependent transferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyses the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S-adenosyl-L-methionine to the C-7 position of 4-demethylwyosine (imG-14) to produce wybutosine-86.
IntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Salivary Carcinoma.
In plain words · TYW2 (tRNA wybutosine-synthesising protein 2 homolog) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Salivary gland cancers.
TYW2 (tRNA wybutosine-synthesising protein 2 homolog) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Salivary gland cancers.
S-adenosyl-L-methionine-dependent transferase that acts as a component of the wybutosine biosynthesis pathway.
No product in this corpus aims at TYW2 yet. Drugs fit a pocket that exists only in one shape of the mutant protein and hold it there, off.
First described 2004. Earliest sequence paper UniProt cites for the protein: Ota et al, Nat. Genet, 2004, "Complete sequencing and characterization of 21,243 full-length human cDNAs". Source.
Sources: HGNC HGNC:26091 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q53H54 (protein name, function text, keywords and locations (REST API)); IntOGen TYW2 (driver in 1 cohort (Act 1, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
S-adenosyl-L-methionine-dependent transferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyses the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S-adenosyl-L-methionine to the C-7 position of 4-demethylwyosine (imG-14) to produce wybutosine-86. Locus 8q24.13 (HGNC).
Query for this target: (TITLE:"TYW2" OR ABSTRACT:"TYW2" OR TITLE:"tRNA wybutosine-synthesizing protein 2" OR ABSTRACT:"tRNA wybutosine-synthesizing protein 2" OR TITLE:"tRNA wybutosine-synthesizing protein 2 homolog" OR ABSTRACT:"tRNA wybutosine-synthesizing protein 2 homolog" OR TITLE:"FLJ20772" OR ABSTRACT:"FLJ20772" OR TITLE:"Trm12" OR ABSTRACT:"Trm12" OR TITLE:"TRMT12" OR ABSTRACT:"TRMT12") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about TYW2, not a curated reading list.
Shares Salivary gland cancers, IntOGen.
Shares Salivary gland cancers, IntOGen.
Shares Salivary gland cancers, IntOGen.
Shares Salivary gland cancers, IntOGen.
Shares Salivary gland cancers, IntOGen.
Shares Salivary gland cancers, IntOGen.
Shares Salivary gland cancers, IntOGen.
Shares Salivary gland cancers, IntOGen.