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ESRRA (Steroid hormone receptor ERR1) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Salivary gland cancers and Adenoid cystic carcinoma.
Binds to an ERR-alpha response element (ERRE) containing a single consensus half-site, 5'-TNAAGGTCA-3'. Can bind to the medium-chain acyl coenzyme A dehydrogenase (MCAD) response element NRRE-1 and may act as an important regulator of MCAD promoter. Binds to the C1 region of the lactoferrin gene promoter.
IntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Adenoid Cystic Carcinoma.
In plain words · ESRRA (Steroid hormone receptor ERR1) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Salivary gland cancers and Adenoid cystic carcinoma.
ESRRA (Steroid hormone receptor ERR1) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Salivary gland cancers and Adenoid cystic carcinoma.
Binds to an ERR-alpha response element (ERRE) containing a single consensus half-site, 5'-TNAAGGTCA-3'.
No product in this corpus aims at ESRRA yet. Drugs fit a pocket that exists only in one shape of the mutant protein and hold it there, off.
First described 1988. Earliest sequence paper UniProt cites for the protein: Giguere et al, Nature, 1988, "Identification of a new class of steroid hormone receptors". Source.
Sources: HGNC HGNC:3471 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P11474 (protein name, function text, keywords and locations (REST API)); IntOGen ESRRA (driver in 1 cohort (Act 1, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Binds to an ERR-alpha response element (ERRE) containing a single consensus half-site, 5'-TNAAGGTCA-3'. Can bind to the medium-chain acyl coenzyme A dehydrogenase (MCAD) response element NRRE-1 and may act as an important regulator of MCAD promoter. Binds to the C1 region of the lactoferrin gene promoter. Requires dimerisation and the coactivator, PGC-1A, for full activity. The ERRalpha/PGC1alpha complex is a regulator of energy metabolism. Induces the expression of PERM1 in the skeletal muscle. Location: Nucleus; Cytoplasm (UniProt). Locus 11q13.1 (HGNC).
Query for this target: (TITLE:"ESRRA" OR ABSTRACT:"ESRRA" OR TITLE:"estrogen related receptor alpha" OR ABSTRACT:"estrogen related receptor alpha" OR TITLE:"Steroid hormone receptor ERR1" OR ABSTRACT:"Steroid hormone receptor ERR1" OR TITLE:"ERR1" OR ABSTRACT:"ERR1" OR TITLE:"ERRalpha" OR ABSTRACT:"ERRalpha" OR TITLE:"NR3B1" OR ABSTRACT:"NR3B1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about ESRRA, not a curated reading list.
Shares Salivary gland cancers, IntOGen.
Shares Salivary gland cancers, IntOGen.
Shares Adenoid cystic carcinoma, Salivary gland cancers, IntOGen.