{"entity":{"id":"crtc1","kind":"target","name":"CRTC1","aka":["CREB regulated transcription coactivator 1","CREB-regulated transcription coactivator 1","KIAA0616","FLJ14027","TORC1","MECT1"],"tldr":"CRTC1 (CREB-regulated transcription coactivator 1) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Salivary gland cancers, Lung cancer, Skin cancer and 5 more.","summary":"Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signalling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4.\n\nOpen Targets scores its association with cancer at 0.67 (direct and indirect evidence; datatypes literature 0.82, animal model 0.26, genetic association 0.26, somatic mutation 0.84). IntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Adenoid Cystic Carcinoma.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:16062","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:16062"},{"label":"UniProt Q6UUV9","url":"https://www.uniprot.org/uniprotkb/Q6UUV9/entry"},{"label":"NCBI Gene 23373","url":"https://www.ncbi.nlm.nih.gov/gene/23373"},{"label":"Ensembl ENSG00000105662","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000105662"}],"tags":["cancer-genes-wave"],"related":["open-targets","intogen"],"cancers":["salivary-gland","lung-cancer","skin-cancer","colorectal","esophageal","mucoepidermoid-carcinoma","adenoid-cystic-carcinoma","oral-cavity-cancer"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort; UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"CRTC1","role":["oncogene-driver","fusion-partner"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:16062","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:16062","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q6UUV9","url":"https://www.uniprot.org/uniprotkb/Q6UUV9/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000105662","url":"https://platform.opentargets.org/target/ENSG00000105662/associations","note":"association with cancer (MONDO_0004992) 0.67; per-cancer scores at or above 0.5: non-small cell lung carcinoma 0.54, colorectal cancer 0.51, oesophageal cancer 0.51, skin cancer 0.51, lung cancer 0.56, oral cavity cancer 0.56 (GraphQL API, CC0)"},{"label":"IntOGen CRTC1","url":"https://www.intogen.org/search?gene=CRTC1","note":"driver in 1 cohort (Act 1, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"specificitySources":[],"hgnc":"HGNC:16062","ensembl":"ENSG00000105662","uniprot":"Q6UUV9","entrez":"23373","firstDescribed":1998,"firstDescribedBasis":"sequence","firstDescribedNote":"Earliest sequence paper UniProt cites for the protein: Ishikawa et al, DNA Res, 1998, \"Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro\".","firstDescribedSource":"https://pubmed.ncbi.nlm.nih.gov/9734811/","biology":"Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signalling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PGC1alpha and inducer of mitochondrial biogenesis in muscle cells. In the hippocampus, involved in late-phase long-term potentiation (L-LTP) maintenance at the Schaffer collateral-CA1 synapses. Location: Cytoplasm; Nucleus (UniProt). Locus 19p13.11 (HGNC).","whereFound":["Salivary gland cancers: IntOGen driver in 1 cohort (ACYC)","Lung cancer: Open Targets association 0.56 with lung cancer (MONDO_0008903)","Skin cancer: Open Targets association 0.51 with skin cancer (MONDO_0002898)","Colorectal cancer: Open Targets association 0.51 with colorectal cancer (MONDO_0005575)","Oesophageal cancer: Open Targets association 0.51 with oesophageal cancer (MONDO_0007576)","Mucoepidermoid carcinoma: Open Targets association 0.58 with mucoepidermoid carcinoma (MONDO_0003036)"],"targetClass":"oncogene","prevalence":[]},"route":"/targets/crtc1/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"},{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"adenoid-cystic-carcinoma","kind":"cancer","name":"Adenoid cystic carcinoma","route":"/cancers/adenoid-cystic-carcinoma/"},{"id":"colorectal","kind":"cancer","name":"Colorectal cancer","route":"/cancers/colorectal/"},{"id":"lung-cancer","kind":"cancer","name":"Lung cancer (all types)","route":"/cancers/lung-cancer/"},{"id":"mucoepidermoid-carcinoma","kind":"cancer","name":"Mucoepidermoid carcinoma","route":"/cancers/mucoepidermoid-carcinoma/"},{"id":"esophageal","kind":"cancer","name":"Oesophageal cancer","route":"/cancers/esophageal/"},{"id":"oral-cavity-cancer","kind":"cancer","name":"Oral cavity cancer (mouth and tongue)","route":"/cancers/oral-cavity-cancer/"},{"id":"salivary-gland","kind":"cancer","name":"Salivary gland cancers","route":"/cancers/salivary-gland/"},{"id":"skin-cancer","kind":"cancer","name":"Skin cancer (all types)","route":"/cancers/skin-cancer/"}]}}