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PLAG1 (Zinc finger protein PLAG1) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Breast cancer, Melanoma and Oral cavity cancer.
Transcription factor whose activation results in up-regulation of target genes, such as IGFII, leading to uncontrolled cell proliferation: when overexpressed in cultured cells, higher proliferation rate and transformation are observed. Other target genes such as CRLF1, CRABP2, CRIP2, PIGF are strongly induced in cells with PLAG1 induction. Proto-oncogene whose ectopic expression can trigger the development of pleomorphic adenomas of the salivary gland and lipoblastomas.
Open Targets scores its association with cancer at 0.69 (direct and indirect evidence; datatypes literature 0.92, genetic association 0.33, somatic mutation 0.87). IntOGen calls it a driver in 2 cohorts (2 activating, 0 loss-of-function), covering Invasive Breast Carcinoma, Cutaneous Melanoma.
In plain words · PLAG1 (Zinc finger protein PLAG1) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Breast cancer, Melanoma and Oral cavity cancer.
PLAG1 (Zinc finger protein PLAG1) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Breast cancer, Melanoma and Oral cavity cancer.
Transcription factor whose activation results in up-regulation of target genes, such as IGFII, leading to uncontrolled cell proliferation: when overexpressed in cultured cells, higher proliferation rate and transformation are observed.
No product in this corpus aims at PLAG1 yet. Drugs fit a pocket that exists only in one shape of the mutant protein and hold it there, off.
First described 1997. Earliest sequence paper UniProt cites for the protein: Kas et al, Nat. Genet, 1997, "Promoter swapping between the genes for a novel zinc finger protein and beta-catenin in pleiomorphic adenomas with t(3;8)(p21;q12) translocations". Source.
Sources: HGNC HGNC:9045 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q6DJT9 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000181690 (association with cancer (MONDO_0004992) 0.69; per-cancer scores at or above 0.5: breast cancer 0.57, oral cavity cancer 0.52 (GraphQL API, CC0)); IntOGen PLAG1 (driver in 2 cohorts (Act 2, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Transcription factor whose activation results in up-regulation of target genes, such as IGFII, leading to uncontrolled cell proliferation: when overexpressed in cultured cells, higher proliferation rate and transformation are observed. Other target genes such as CRLF1, CRABP2, CRIP2, PIGF are strongly induced in cells with PLAG1 induction. Proto-oncogene whose ectopic expression can trigger the development of pleomorphic adenomas of the salivary gland and lipoblastomas. Overexpression is associated with up-regulation of IGFII, is frequently observed in hepatoblastoma, common primary liver tumour in childhood. Cooperates with CBFB-MYH11, a fusion gene important for myeloid leukaemia. Location: Nucleus (UniProt). Locus 8q12.1 (HGNC).
Query for this target: (TITLE:"PLAG1" OR ABSTRACT:"PLAG1" OR TITLE:"PLAG1 zinc finger" OR ABSTRACT:"PLAG1 zinc finger" OR TITLE:"Zinc finger protein PLAG1" OR ABSTRACT:"Zinc finger protein PLAG1" OR TITLE:"ZNF912" OR ABSTRACT:"ZNF912") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about PLAG1, not a curated reading list.
Shares Oral cavity cancer (mouth and tongue), Breast cancer (all types), Open Targets Platform.
Shares Oral cavity cancer (mouth and tongue), Breast cancer (all types), Open Targets Platform.
Shares Oral cavity cancer (mouth and tongue), Breast cancer (all types), Open Targets Platform.
Shares Oral cavity cancer (mouth and tongue), Open Targets Platform.
Shares Oral cavity cancer (mouth and tongue), Open Targets Platform.
Shares Oral cavity cancer (mouth and tongue), Open Targets Platform.
Shares Oral cavity cancer (mouth and tongue), Breast cancer (all types), Melanoma, Open Targets Platform.
Shares Oral cavity cancer (mouth and tongue), IntOGen, Breast cancer (all types), Open Targets Platform.