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HMGA2 (High mobility group protein HMGI-C) is a protein that switches other genes on and off. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Breast cancer and Oral cavity cancer.
Functions as a transcriptional regulator. Functions in cell cycle regulation through CCNA2. Plays an important role in chromosome condensation during the meiotic G2/M transition of spermatocytes.
Open Targets scores its association with cancer at 0.70 (direct and indirect evidence; datatypes literature 1.00, animal model 0.36, genetic association 0.49, somatic mutation 0.98).
In plain words · HMGA2 (High mobility group protein HMGI-C) is a protein that switches other genes on and off. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Breast cancer and Oral cavity cancer.
HMGA2 (High mobility group protein HMGI-C) is a protein that switches other genes on and off. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Breast cancer and Oral cavity cancer.
Functions as a transcriptional regulator. Functions in cell cycle regulation through CCNA2.
No product in this corpus aims at HMGA2 yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
First described 1994. Earliest sequence paper UniProt cites for the protein: Patel U.A. et al, Biochem. Biophys. Res. Commun, 1994, "Expression and cDNA cloning of human HMGI-C phosphoprotein". Source.
Sources: HGNC HGNC:5009 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P52926 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000149948 (association with cancer (MONDO_0004992) 0.70; per-cancer scores at or above 0.5: breast cancer 0.56, oral cavity cancer 0.52 (GraphQL API, CC0))
Functions as a transcriptional regulator. Functions in cell cycle regulation through CCNA2. Plays an important role in chromosome condensation during the meiotic G2/M transition of spermatocytes. Plays a role in postnatal myogenesis, is involved in satellite cell activation. Positively regulates IGF2 expression through PLAG1 and in a PLAG1-independent manner. Location: Nucleus (UniProt). Locus 12q14.3 (HGNC).
Query for this target: (TITLE:"HMGA2" OR ABSTRACT:"HMGA2" OR TITLE:"high mobility group AT-hook 2" OR ABSTRACT:"high mobility group AT-hook 2" OR TITLE:"High mobility group protein HMGI-C" OR ABSTRACT:"High mobility group protein HMGI-C" OR TITLE:"HMGIC" OR ABSTRACT:"HMGIC") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about HMGA2, not a curated reading list.
Shares Oral cavity cancer (mouth and tongue), Breast cancer (all types), Open Targets Platform.
Shares Oral cavity cancer (mouth and tongue), Open Targets Platform.
Shares Oral cavity cancer (mouth and tongue), Open Targets Platform.
Shares Oral cavity cancer (mouth and tongue), Open Targets Platform.
Shares Oral cavity cancer (mouth and tongue), Breast cancer (all types), Open Targets Platform.
Shares Oral cavity cancer (mouth and tongue), Breast cancer (all types), Open Targets Platform.
Shares Oral cavity cancer (mouth and tongue), Breast cancer (all types), Open Targets Platform.
Shares Oral cavity cancer (mouth and tongue), Breast cancer (all types), Open Targets Platform.