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CHCHD7 (Coiled-coil-helix-coiled-coil-helix domain-containing protein 7) is a gene. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Oral cavity cancer.
UniProt has no function text for Q9BUK0; HGNC names it "coiled-coil-helix-coiled-coil-helix domain containing 7".
Open Targets scores its association with cancer at 0.56 (direct and indirect evidence; datatypes literature 0.10, genetic association 0.09, somatic mutation 0.89).
In plain words · CHCHD7 (Coiled-coil-helix-coiled-coil-helix domain-containing protein 7) is a gene. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Oral cavity cancer.
CHCHD7 (Coiled-coil-helix-coiled-coil-helix domain-containing protein 7) is a gene. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Oral cavity cancer.
UniProt has no function text for Q9BUK0; HGNC names it "coiled-coil-helix-coiled-coil-helix domain containing 7". Location: Mitochondrion intermembrane space (UniProt).
No product in this corpus aims at CHCHD7 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
First described 2001. Earliest sequence paper UniProt cites for the protein: Guo J.H. et al, 2001. Source.
Sources: HGNC HGNC:28314 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9BUK0 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000170791 (association with cancer (MONDO_0004992) 0.56; per-cancer scores at or above 0.5: oral cavity cancer 0.51 (GraphQL API, CC0))
UniProt has no function text for Q9BUK0; HGNC names it "coiled-coil-helix-coiled-coil-helix domain containing 7". Location: Mitochondrion intermembrane space (UniProt). Locus 8q12.1 (HGNC).
Query for this target: (TITLE:"CHCHD7" OR ABSTRACT:"CHCHD7" OR TITLE:"coiled-coil-helix-coiled-coil-helix domain containing 7" OR ABSTRACT:"coiled-coil-helix-coiled-coil-helix domain containing 7" OR TITLE:"Coiled-coil-helix-coiled-coil-helix domain-containing protein 7" OR ABSTRACT:"Coiled-coil-helix-coiled-coil-helix domain-containing protein 7" OR TITLE:"MGC2217" OR ABSTRACT:"MGC2217" OR TITLE:"COX23" OR ABSTRACT:"COX23") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about CHCHD7, not a curated reading list.
Shares Oral cavity cancer (mouth and tongue), Open Targets Platform.
Shares Oral cavity cancer (mouth and tongue), Open Targets Platform.
Shares Oral cavity cancer (mouth and tongue), Open Targets Platform.
Shares Oral cavity cancer (mouth and tongue), Open Targets Platform.
Shares Oral cavity cancer (mouth and tongue), Open Targets Platform.
Shares Oral cavity cancer (mouth and tongue), Open Targets Platform.
Shares Oral cavity cancer (mouth and tongue), Open Targets Platform.
Shares Oral cavity cancer (mouth and tongue), Open Targets Platform.