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CRTC3 (CREB-regulated transcription coactivator 3) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role. Tied to Oral cavity cancer.
Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signalling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4.
Open Targets scores its association with cancer at 0.64 (direct and indirect evidence; datatypes literature 0.68, genetic association 0.31, somatic mutation 0.78).
In plain words · CRTC3 (CREB-regulated transcription coactivator 3) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role. Tied to Oral cavity cancer.
CRTC3 (CREB-regulated transcription coactivator 3) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role. Tied to Oral cavity cancer.
Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites.
No product in this corpus aims at CRTC3 yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
First described 2003. Earliest sequence paper UniProt cites for the protein: Iourgenko et al, Proc. Natl. Acad. Sci. U.S.A, 2003, "Identification of a family of cAMP response element-binding protein coactivators by genome-scale functional analysis in mammalian cells". Source.
Sources: HGNC HGNC:26148 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q6UUV7 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000140577 (association with cancer (MONDO_0004992) 0.64; per-cancer scores at or above 0.5: oral cavity cancer 0.53 (GraphQL API, CC0))
Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signalling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukaemia virus type 1 (HTLV-1) long terminal repeats (LTR). Location: Nucleus; Cytoplasm (UniProt). Locus 15q26.1 (HGNC).
Query for this target: (TITLE:"CRTC3" OR ABSTRACT:"CRTC3" OR TITLE:"CREB regulated transcription coactivator 3" OR ABSTRACT:"CREB regulated transcription coactivator 3" OR TITLE:"CREB-regulated transcription coactivator 3" OR ABSTRACT:"CREB-regulated transcription coactivator 3" OR TITLE:"FLJ21868" OR ABSTRACT:"FLJ21868") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about CRTC3, not a curated reading list.
Shares Oral cavity cancer (mouth and tongue), Open Targets Platform.
Shares Oral cavity cancer (mouth and tongue), Open Targets Platform.
Shares Oral cavity cancer (mouth and tongue), Open Targets Platform.
Shares Oral cavity cancer (mouth and tongue), Open Targets Platform.
Shares Oral cavity cancer (mouth and tongue), Open Targets Platform.
Shares Oral cavity cancer (mouth and tongue), Open Targets Platform.
Shares Oral cavity cancer (mouth and tongue), Open Targets Platform.
Shares Oral cavity cancer (mouth and tongue), Open Targets Platform.