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TCEA1 (Transcription elongation factor A protein 1) is a protein that switches other genes on and off. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Oral cavity cancer.
Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus.
Open Targets scores its association with cancer at 0.55 (direct and indirect evidence; datatypes literature 0.23, genetic association 0.00, somatic mutation 0.89).
In plain words · TCEA1 (Transcription elongation factor A protein 1) is a protein that switches other genes on and off. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Oral cavity cancer.
TCEA1 (Transcription elongation factor A protein 1) is a protein that switches other genes on and off. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Oral cavity cancer.
Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites.
No product in this corpus aims at TCEA1 yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
First described 1991. Earliest sequence paper UniProt cites for the protein: Yoo et al, Nucleic Acids Res, 1991, "Cloning, expression and characterization of the human transcription elongation factor, TFIIS". Source.
Sources: HGNC HGNC:11612 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P23193 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000187735 (association with cancer (MONDO_0004992) 0.55; per-cancer scores at or above 0.5: oral cavity cancer 0.51 (GraphQL API, CC0))
Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus. Location: Nucleus (UniProt). Locus 8q11.23 (HGNC).
Query for this target: (TITLE:"TCEA1" OR ABSTRACT:"TCEA1" OR TITLE:"transcription elongation factor A1" OR ABSTRACT:"transcription elongation factor A1" OR TITLE:"Transcription elongation factor A protein 1" OR ABSTRACT:"Transcription elongation factor A protein 1" OR TITLE:"TF2S" OR ABSTRACT:"TF2S" OR TITLE:"TFIIS" OR ABSTRACT:"TFIIS" OR TITLE:"GTF2S" OR ABSTRACT:"GTF2S") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about TCEA1, not a curated reading list.
Shares Oral cavity cancer (mouth and tongue), Open Targets Platform.
Shares Oral cavity cancer (mouth and tongue), Open Targets Platform.
Shares Oral cavity cancer (mouth and tongue), Open Targets Platform.
Shares Oral cavity cancer (mouth and tongue), Open Targets Platform.
Shares Oral cavity cancer (mouth and tongue), Open Targets Platform.
Shares Oral cavity cancer (mouth and tongue), Open Targets Platform.
Shares Oral cavity cancer (mouth and tongue), Open Targets Platform.
Shares Oral cavity cancer (mouth and tongue), Open Targets Platform.