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MYB (Transcriptional activator Myb) is a protein that switches other genes on and off. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Skin cancer, Breast cancer, Colorectal cancer and 5 more.
Transcriptional activator; DNA-binding protein that specifically recognise the sequence 5'-YAAC[GT]G-3'. Plays an important role in the control of proliferation and differentiation of haematopoietic progenitor cells.
CIViC holds 7 clinical evidence items and 2 assertions across 3 variants. Open Targets scores its association with cancer at 0.69 (direct and indirect evidence; datatypes affected pathway 0.44, literature 0.99, genetic association 0.10, somatic mutation 0.98, animal model 0.71).
In plain words · MYB (Transcriptional activator Myb) is a protein that switches other genes on and off. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Skin cancer, Breast cancer, Colorectal cancer and 5 more.
MYB (Transcriptional activator Myb) is a protein that switches other genes on and off. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Skin cancer, Breast cancer, Colorectal cancer and 5 more.
Transcriptional activator; DNA-binding protein that specifically recognise the sequence 5'-YAAC[GT]G-3'. Plays an important role in the control of proliferation and differentiation of haematopoietic progenitor cells.
No product in this corpus aims at MYB yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
Specificity not established: no corpus medicine is aimed at it and the catalogues give it only the role biomarker; HPA finds the RNA group enriched, which says where the protein sits but not whether the tumour differs from normal tissue. HPA MYB: RNA group enriched (bone marrow 33 nTPM, breast 19 nTPM, intestine 25 nTPM); blood lineage group enriched (dendritic cells 2 nTPM, granulocytes 5 nTPM); high antibody staining in 11 normal tissues; highest cancer staining urothelial cancer (10 of 10 high). Distribution: 7 cancer families in the corpus carry a prevalence row, label threshold or catalogue link for it (Skin cancer (all types), Breast cancer (all types), Colorectal cancer, Leukaemia, Lymphoma, Brain and spinal cord tumours (all types), Head and neck squamous cell carcinoma); Open Targets associates it with 0 specific cancer types at or above 0.5. (No rule of scripts/fetch-target-specificity.ts fired.)
Sources: Human Protein Atlas MYB tissue; Open Targets ENSG00000118513 associations
First described 1986. Earliest sequence paper UniProt cites for the protein: Majello et al, Proc. Natl. Acad. Sci. U.S.A, 1986, "Human c-myb protooncogene: nucleotide sequence of cDNA and organization of the genomic locus". Source.
Sources: HGNC HGNC:7545 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P10242 (protein name, function text, keywords and locations (REST API)); CIViC gene MYB (7 evidence items, 2 assertions, 3 variants; diseases: Diffuse Astrocytoma, MYB- Or MYBL1-altered, Angiocentric Glioma, Childhood Low-grade Glioma, Isomorphic Diffuse Glioma (GraphQL API, CC0)); Open Targets ENSG00000118513 (association with cancer (MONDO_0004992) 0.69; per-cancer scores at or above 0.5: colorectal cancer 0.55, melanoma 0.57, non-Hodgkin lymphoma 0.52, skin cancer 0.58, breast cancer 0.56, leukaemia 0.52 (GraphQL API, CC0))
Transcriptional activator; DNA-binding protein that specifically recognise the sequence 5'-YAAC[GT]G-3'. Plays an important role in the control of proliferation and differentiation of haematopoietic progenitor cells. Location: Nucleus (UniProt). Locus 6q23.3 (HGNC).
RNA: group enriched (bone marrow 33 nTPM, breast 19 nTPM, intestine 25 nTPM, lymphoid tissue 62 nTPM), detected in many normal tissues. Blood: group enriched (dendritic cells 2 nTPM, granulocytes 5 nTPM).
Medium: Breast, Bronchus, Cervix, Duodenum, Small intestine, Vagina.
RNA group enriched: Breast Invasive Carcinoma 38 pTPM, Colon Adenocarcinoma 33 pTPM, Rectum Adenocarcinoma 36 pTPM, Stomach Adenocarcinoma 13 pTPM.
Medium only: renal cancer.
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"MYB" OR ABSTRACT:"MYB" OR TITLE:"MYB proto-oncogene, transcription factor" OR ABSTRACT:"MYB proto-oncogene, transcription factor" OR TITLE:"Transcriptional activator Myb" OR ABSTRACT:"Transcriptional activator Myb" OR TITLE:"c-myb" OR ABSTRACT:"c-myb") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about MYB, not a curated reading list.
Shares Leukaemia (all types), Skin cancer (all types), Breast cancer (all types), Non-Hodgkin lymphoma (all types).
Shares Leukaemia (all types), Skin cancer (all types), CIViC, Breast cancer (all types).
Shares Leukaemia (all types), Skin cancer (all types), Breast cancer (all types), Non-Hodgkin lymphoma (all types).
Shares Leukaemia (all types), Skin cancer (all types), CIViC, Melanoma.
Shares Leukaemia (all types), Skin cancer (all types), CIViC, Breast cancer (all types).
Shares Leukaemia (all types), Skin cancer (all types), Non-Hodgkin lymphoma (all types), Melanoma.
Shares Leukaemia (all types), CIViC, Breast cancer (all types), Non-Hodgkin lymphoma (all types).
Shares Paediatric low-grade glioma, Skin cancer (all types), Breast cancer (all types), Melanoma.