{"entity":{"id":"myb","kind":"target","name":"MYB","aka":["MYB proto-oncogene, transcription factor","Transcriptional activator Myb","c-myb"],"tldr":"MYB (Transcriptional activator Myb) is a protein that switches other genes on and off. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Skin cancer, Breast cancer, Colorectal cancer and 5 more.","summary":"Transcriptional activator; DNA-binding protein that specifically recognise the sequence 5'-YAAC[GT]G-3'. Plays an important role in the control of proliferation and differentiation of haematopoietic progenitor cells.\n\nCIViC holds 7 clinical evidence items and 2 assertions across 3 variants. Open Targets scores its association with cancer at 0.69 (direct and indirect evidence; datatypes affected pathway 0.44, literature 0.99, genetic association 0.10, somatic mutation 0.98, animal model 0.71).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:7545","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7545"},{"label":"UniProt P10242","url":"https://www.uniprot.org/uniprotkb/P10242/entry"},{"label":"NCBI Gene 4602","url":"https://www.ncbi.nlm.nih.gov/gene/4602"},{"label":"Ensembl ENSG00000118513","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000118513"}],"tags":["cancer-genes-wave"],"related":["civic","open-targets"],"cancers":["skin-cancer","breast-cancer","colorectal","leukaemia","non-hodgkin-lymphoma","paediatric-low-grade-glioma","melanoma","oral-cavity-cancer"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC holds 7 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate.","Diseases the sources name that have no OnCo cancer page yet, so they are not linked: Diffuse Astrocytoma, MYB- Or MYBL1-altered; Angiocentric Glioma; Isomorphic Diffuse Glioma."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"MYB","role":["biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:7545","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7545","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P10242","url":"https://www.uniprot.org/uniprotkb/P10242/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene MYB","url":"https://civicdb.org/features/3730","note":"7 evidence items, 2 assertions, 3 variants; diseases: Diffuse Astrocytoma, MYB- Or MYBL1-altered, Angiocentric Glioma, Childhood Low-grade Glioma, Isomorphic Diffuse Glioma (GraphQL API, CC0)"},{"label":"Open Targets ENSG00000118513","url":"https://platform.opentargets.org/target/ENSG00000118513/associations","note":"association with cancer (MONDO_0004992) 0.69; per-cancer scores at or above 0.5: colorectal cancer 0.55, melanoma 0.57, non-Hodgkin lymphoma 0.52, skin cancer 0.58, breast cancer 0.56, leukaemia 0.52 (GraphQL API, CC0)"}],"distribution":"many-types","specificityNote":"Specificity not established: no corpus medicine is aimed at it and the catalogues give it only the role biomarker; HPA finds the RNA group enriched, which says where the protein sits but not whether the tumour differs from normal tissue. HPA MYB: RNA group enriched (bone marrow 33 nTPM, breast 19 nTPM, intestine 25 nTPM); blood lineage group enriched (dendritic cells 2 nTPM, granulocytes 5 nTPM); high antibody staining in 11 normal tissues; highest cancer staining urothelial cancer (10 of 10 high). Distribution: 7 cancer families in the corpus carry a prevalence row, label threshold or catalogue link for it (Skin cancer (all types), Breast cancer (all types), Colorectal cancer, Leukaemia, Lymphoma, Brain and spinal cord tumours (all types), Head and neck squamous cell carcinoma); Open Targets associates it with 0 specific cancer types at or above 0.5. (No rule of scripts/fetch-target-specificity.ts fired.)","specificitySources":[{"label":"Human Protein Atlas MYB tissue","url":"https://www.proteinatlas.org/ENSG00000118513-MYB/tissue","note":"RNA tissue and blood lineage specificity, normal tissue antibody staining (version 25.1, CC BY-SA 3.0)"},{"label":"Open Targets ENSG00000118513 associations","url":"https://platform.opentargets.org/target/ENSG00000118513/associations","note":"cancer associations at or above 0.5 (CC0)"}],"hgnc":"HGNC:7545","ensembl":"ENSG00000118513","uniprot":"P10242","entrez":"4602","firstDescribed":1986,"firstDescribedBasis":"sequence","firstDescribedNote":"Earliest sequence paper UniProt cites for the protein: Majello et al, Proc. Natl. Acad. Sci. U.S.A, 1986, \"Human c-myb protooncogene: nucleotide sequence of cDNA and organization of the genomic locus\".","firstDescribedSource":"https://pubmed.ncbi.nlm.nih.gov/3540945/","biology":"Transcriptional activator; DNA-binding protein that specifically recognise the sequence 5'-YAAC[GT]G-3'. Plays an important role in the control of proliferation and differentiation of haematopoietic progenitor cells. Location: Nucleus (UniProt). Locus 6q23.3 (HGNC).","whereFound":["Skin cancer: Open Targets association 0.58 with skin cancer (MONDO_0002898)","Breast cancer: Open Targets association 0.56 with breast cancer (MONDO_0007254)","Colorectal cancer: Open Targets association 0.55 with colorectal cancer (MONDO_0005575)","Leukaemia: Open Targets association 0.52 with leukaemia (MONDO_0005059)","Non-Hodgkin lymphoma: Open Targets association 0.52 with non-Hodgkin lymphoma (MONDO_0018908)","Paediatric low-grade glioma: CIViC evidence names this disease"],"targetClass":"transcription","prevalence":[]},"route":"/targets/myb/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"},{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"breast-cancer","kind":"cancer","name":"Breast cancer (all types)","route":"/cancers/breast-cancer/"},{"id":"colorectal","kind":"cancer","name":"Colorectal cancer","route":"/cancers/colorectal/"},{"id":"leukaemia","kind":"cancer","name":"Leukaemia (all types)","route":"/cancers/leukaemia/"},{"id":"melanoma","kind":"cancer","name":"Melanoma","route":"/cancers/melanoma/"},{"id":"non-hodgkin-lymphoma","kind":"cancer","name":"Non-Hodgkin lymphoma (all types)","route":"/cancers/non-hodgkin-lymphoma/"},{"id":"oral-cavity-cancer","kind":"cancer","name":"Oral cavity cancer (mouth and tongue)","route":"/cancers/oral-cavity-cancer/"},{"id":"paediatric-low-grade-glioma","kind":"cancer","name":"Paediatric low-grade glioma","route":"/cancers/paediatric-low-grade-glioma/"},{"id":"skin-cancer","kind":"cancer","name":"Skin cancer (all types)","route":"/cancers/skin-cancer/"}]}}