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WIF1 (Wnt inhibitory factor 1) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Breast cancer and Oral cavity cancer.
Binds to WNT proteins and inhibits their activities. May be involved in mesoderm segmentation.
Open Targets scores its association with cancer at 0.63 (direct and indirect evidence; datatypes literature 0.97, genetic association 0.19, somatic mutation 0.97).
In plain words · WIF1 (Wnt inhibitory factor 1) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Breast cancer and Oral cavity cancer.
WIF1 (Wnt inhibitory factor 1) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Breast cancer and Oral cavity cancer.
Binds to WNT proteins and inhibits their activities. May be involved in mesoderm segmentation.
No product in this corpus aims at WIF1 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
First described 1999. Earliest sequence paper UniProt cites for the protein: Hsieh J.-C. et al, Nature, 1999, "A new secreted protein that binds to Wnt proteins and inhibits their activities". Source.
Sources: HGNC HGNC:18081 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9Y5W5 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000156076 (association with cancer (MONDO_0004992) 0.63; per-cancer scores at or above 0.5: breast cancer 0.55, oral cavity cancer 0.51 (GraphQL API, CC0))
Binds to WNT proteins and inhibits their activities. May be involved in mesoderm segmentation. Location: Secreted (UniProt). Locus 12q14.3 (HGNC).
Query for this target: (TITLE:"WIF1" OR ABSTRACT:"WIF1" OR TITLE:"Wnt inhibitory factor 1" OR ABSTRACT:"Wnt inhibitory factor 1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about WIF1, not a curated reading list.
Shares Oral cavity cancer (mouth and tongue), Breast cancer (all types), Open Targets Platform.
Shares Oral cavity cancer (mouth and tongue), Open Targets Platform.
Shares Oral cavity cancer (mouth and tongue), Open Targets Platform.
Shares Oral cavity cancer (mouth and tongue), Open Targets Platform.
Shares Oral cavity cancer (mouth and tongue), Breast cancer (all types), Open Targets Platform.
Shares Oral cavity cancer (mouth and tongue), Breast cancer (all types), Open Targets Platform.
Shares Oral cavity cancer (mouth and tongue), Breast cancer (all types), Open Targets Platform.
Shares Oral cavity cancer (mouth and tongue), Breast cancer (all types), Open Targets Platform.