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Curated databases that say what each mutation means for treatment, and the expert meetings that use them to decide on therapy.
OncoKB (MSK; FDA-recognised), CIViC (WashU; open, crowd-curated), My Cancer Genome (Vanderbilt), JAX-CKB, COSMIC (Sanger), ClinVar, and cBioPortal supply the evidence layer for precision oncology; molecular tumour boards (institutional, national such as the UK's Genomic MDTs, and virtual services from Roche NAVIFY, Syapse, and Tempus) apply it to patients. Studies show actionable findings in 30-50% of sequenced patients but treatment uptake of only 10-25%, pointing to access and evidence gaps.
Expert curation of gene-variant-disease-drug evidence into levels (e.g. OncoKB 1-4, R1-R2), exposed by API for lab reporting and decision support.
Nothing recorded yet: a foundation, or a gap to fill.
Dependencies are what this technology cannot be delivered without: manufacturing steps, instruments, software, upstream methods. See its full chain on the map.
One technology page on OnCo cites this paper by its DOI; this record gives the citation a page of its own so a reader can follow it without leaving OnCo. Read the abstract above alongside the citing page listed under Related; the record was created automatically from the Europe PMC entry and its figures have not been checked by hand.
One technology page on OnCo cites this paper by its DOI; this record gives the citation a page of its own so a reader can follow it without leaving OnCo. Read the abstract above alongside the citing page listed under Related; the record was created automatically from the Europe PMC entry and its figures have not been checked by hand.
Query for this technology: (TITLE:"Cancer variant knowledgebases and molecular tumour boards" OR ABSTRACT:"Cancer variant knowledgebases and molecular tumour boards") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Cancer variant knowledgebases and molecular tumour boards, not a curated reading list.
Shares Clinical NGS bioinformatics and variant interpretation, Comprehensive genomic profiling and the tag supporting.
Shares Clinical NGS bioinformatics and variant interpretation and the tag supporting.
Shares Clinical NGS bioinformatics and variant interpretation and the tag supporting.
Shares Diagnostics roadmap: stains → gene panels → blood tests that decide treatment, Comprehensive genomic profiling and the tag supporting.
Shares AI trial matching & clinical decision support and the tag supporting.
Shares Clinical NGS bioinformatics and variant interpretation and the tag supporting.
Shares Comprehensive genomic profiling and the tag supporting.
Shares Diagnostics roadmap: stains → gene panels → blood tests that decide treatment and the tag supporting.
Open-source projects that implement or serve this technology, from OnCo's own catalogue: licence and last activity as the repository reported them on the day of the fetch. Listing is not endorsement; check the licence before reuse and the validation before clinical use.
The open platform for exploring multidimensional cancer genomics data, hosting TCGA, GENIE and hundreds of studies and installed at cancer centres worldwide.
Sean Davis's curated list of cancer variant databases and resources.
A modular variant annotation platform with a store of annotators, including cancer-specific ones, and a browser-based results viewer.
Scripts that annotate MAF, copy-number and fusion files with OncoKB levels of evidence through its API token.
The Global Alliance for Genomics and Health standard for computable, unambiguous variant identifiers.
The browser front end of CIViC.
The variant annotation service behind cBioPortal, aggregating many annotation sources behind one API.
The Drug Gene Interaction Database aggregates druggable genes and drug-gene interactions from many sources with an open API.
Commercial and regulated products that serve this technology. Each card says what is behind it: a regulator's database, the literature, a public body's list, or only the company's own words. Listing is not endorsement, and a clearance is a regulatory fact, not a clinical one.
A comprehensive genomic profiling test and the report software around it, approved as a companion diagnostic for a long and growing list of drugs.
A sequencing panel and the interpretation platform Tempus reports it through, sold alongside its real-world data and trial-matching products.
The Catalogue of Somatic Mutations in Cancer: the reference list of what has been seen mutated in tumours, free for academic use and licensed for everything else.
A variant interpretation platform with a community layer, free at the point of use for individual curators and sold to laboratories.
A search engine over the genomic literature that returns the papers naming a given variant, used as the evidence step in variant classification.
A case management and sign-out environment for molecular pathology, tracking a tumour case from sequencing run to signed report.