{"entity":{"id":"variant-knowledgebases","kind":"technology","name":"Cancer variant knowledgebases and molecular tumour boards","aka":[],"tldr":"Curated databases that say what each mutation means for treatment, and the expert meetings that use them to decide on therapy.","summary":"OncoKB (MSK; FDA-recognised), CIViC (WashU; open, crowd-curated), My Cancer Genome (Vanderbilt), JAX-CKB, COSMIC (Sanger), ClinVar, and cBioPortal supply the evidence layer for precision oncology; molecular tumour boards (institutional, national such as the UK's Genomic MDTs, and virtual services from Roche NAVIFY, Syapse, and Tempus) apply it to patients. Studies show actionable findings in 30-50% of sequenced patients but treatment uptake of only 10-25%, pointing to access and evidence gaps.","status":"established","asOf":"2026-09-08","links":[{"label":"Chakravarty et al., OncoKB: a precision oncology knowledge base (JCO Precision Oncology 2017)","url":"https://doi.org/10.1200/PO.17.00011"},{"label":"Griffith et al., CIViC is a community knowledgebase for expert crowdsourcing the clinical interpretation of variants in cancer (Nature Genetics 2017)","url":"https://doi.org/10.1038/ng.3774"}],"tags":["supporting"],"related":["oncokb","civic","cbioportal"],"cancers":[],"sections":["diagnostics","ai-computation"],"technologies":["cgp","ngs-bioinformatics-software","ai-trial-matching"],"targets":[],"drugs":[],"companies":[],"institutions":["mskcc"],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":["paper-griffith-nat-genet","paper-chakravarty-jco-precis-oncol"],"journals":[],"dependsOn":[],"notes":[],"principle":"Expert curation of gene-variant-disease-drug evidence into levels (e.g. OncoKB 1-4, R1-R2), exposed by API for lab reporting and decision support.","strengths":["Open, citable evidence","Regulatory recognition (OncoKB)"],"limitations":["Curation lag and disagreement between sources","Sparse evidence for rare variants","Tumour-board capacity"]},"route":"/technologies/variant-knowledgebases/","neighbours":{"collection":[{"id":"cbioportal","kind":"collection","name":"cBioPortal for Cancer Genomics","route":"/collections/cbioportal/"},{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"},{"id":"oncokb","kind":"collection","name":"OncoKB","route":"/collections/oncokb/"}],"section":[{"id":"ai-computation","kind":"section","name":"AI & Computation","route":"/fronts/ai-computation/"},{"id":"diagnostics","kind":"section","name":"Diagnostics & Biomarkers","route":"/fronts/diagnostics/"}],"technology":[{"id":"ai-trial-matching","kind":"technology","name":"AI trial matching & clinical decision support","route":"/technologies/ai-trial-matching/"},{"id":"ngs-bioinformatics-software","kind":"technology","name":"Clinical NGS bioinformatics and variant interpretation","route":"/technologies/ngs-bioinformatics-software/"},{"id":"cgp","kind":"technology","name":"Comprehensive genomic profiling","route":"/technologies/cgp/"}],"institution":[{"id":"mskcc","kind":"institution","name":"Memorial Sloan Kettering Cancer Center","route":"/institutions/mskcc/"}],"paper":[{"id":"paper-griffith-nat-genet","kind":"paper","name":"CIViC is a community knowledgebase for expert crowdsourcing the clinical interpretation of variants in cancer","route":"/key-papers/paper-griffith-nat-genet/"},{"id":"paper-chakravarty-jco-precis-oncol","kind":"paper","name":"OncoKB: A Precision Oncology Knowledge Base","route":"/key-papers/paper-chakravarty-jco-precis-oncol/"}],"roadmap":[{"id":"diagnostics-roadmap","kind":"roadmap","name":"Diagnostics roadmap: stains → gene panels → blood tests that decide treatment","route":"/roadmaps/diagnostics-roadmap/"}],"trial":[{"id":"i-predict","kind":"trial","name":"I-PREDICT","route":"/trials/i-predict/"},{"id":"nci-match","kind":"trial","name":"NCI-MATCH (EAY131)","route":"/trials/nci-match/"},{"id":"tapur","kind":"trial","name":"TAPUR (Targeted Agent and Profiling Utilization Registry)","route":"/trials/tapur/"},{"id":"target-national","kind":"trial","name":"TARGET National","route":"/trials/target-national/"},{"id":"winther","kind":"trial","name":"WINTHER","route":"/trials/winther/"}]}}