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Software, increasingly LLM-based, that reads a patient's record and finds trials or guideline options they qualify for.
AI trial matching software extracts structured data from the electronic health record, matches it against parsed eligibility criteria, and ranks trials or guideline options a patient may qualify for. The problem it targets is that only around 5-8% of adult cancer patients enter trials, partly because matching is manual. Tools include TrialGPT (NIH), Tempus TIME, Massive Bio, Deep 6 AI, and hospital-built LLM matchers, and molecular tumour boards use OncoKB and CIViC annotation for variant interpretation. The approach scales expert knowledge and could reduce disparities in trial access, but hallucination risk and the need for validation are live concerns, and eligibility criteria are often ambiguous even to humans. Evidence of increased enrolment is emerging but not yet definitive. The simple version is software that reads a patient's record and finds the trials they could join.
Structured data are extracted from the EHR, matched against parsed eligibility criteria, and ranked.
Query for this technology: (TITLE:"clinical trial matching" OR ABSTRACT:"clinical trial matching" OR TITLE:"trial eligibility" OR ABSTRACT:"trial eligibility" OR TITLE:"large language model" OR ABSTRACT:"large language model") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about AI trial matching & clinical decision support, not a curated reading list.
Shares Galen, Klineo, Picnic Health.
Shares Direct record-to-database data capture: no manual transcription, no full source verification, Dynamic consent with usage receipts, A live 'seats available' feed for trial slots, like airline inventory, Trial matching inside the electronic record at the moment a treatment is chosen.
Shares Just-in-time site activation: open a site in two weeks when a patient appears, N-of-1 and rapid platform trials, A national platform trial that every ctDNA-positive patient can join, One standing umbrella trial for all rare cancers in a country.
Open-source projects that implement or serve this technology, from OnCo's own catalogue: licence and last activity as the repository reported them on the day of the fetch. Listing is not endorsement; check the licence before reuse and the validation before clinical use.
A Model Context Protocol server that gives AI assistants structured access to trials, variants and literature for oncology questions.
The NIH's language-model method for matching patients to clinical trials, code released in the public domain.
An open AI pipeline for matching cancer patients to clinical trials from their records.
Commercial and regulated products that serve this technology. Each card says what is behind it: a regulator's database, the literature, a public body's list, or only the company's own words. Listing is not endorsement, and a clearance is a regulatory fact, not a clinical one.
A patient application with a navigation and question-answering layer, with trial matching and record collection inside the same app.
A matching engine embedded in patient advocacy websites, turning the registry's free text into questions a person can answer.
A case review workspace aimed at cancer foundations and their clinical teams, bringing a person's records, reports, imaging and genomic results into one place alongside trial search.
Trial matching infrastructure sold to advocacy groups and sponsors, with a structured version of the registry's eligibility criteria underneath.
A patient-facing trial matching service that asks about the diagnosis and treatment history and returns studies that fit.
A trial matching service for patients and their doctors, combining an algorithm over the public registry with a human team that works the case.
Open-source software, hardware and data projects catalogued by a third party, the Open Medical Registry, that bear on this technology. Listing is not endorsement; check each project's own licence and validation before clinical use.
AI patient advocacy tool for cancer treatment.
TrialMatchAI leverages large language models to streamline clinical trial matching by evaluating patient-specific clinical characteristics against trial...
From the Open Medical Registry (openmedical.sh), an MIT-licensed catalogue of open-source medicine. Blurbs are one line from each registry record; every project keeps its own licence.