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How many patients a trial has signed up, and how fast. Slow accrual is the commonest reason trials take years longer than planned or close without an answer; only about 5-8% of adult cancer patients ever join a trial.
Accrual depends on the number of eligible patients (narrow eligibility criteria excluding older patients, brain metastases, poor performance status or prior therapies), site activation speed, competing trials, patient awareness and travel burden, with large inequities by race, geography and income. Remedies include broader eligibility (ASCO/Friends of Cancer Research recommendations), decentralised and hybrid trials, community oncology site networks, AI trial matching, and paying for travel. Rare cancers and paediatric trials often need international consortia and a decade to accrue; 'closed to accrual' means the target number was reached and follow-up continues.
Showing the technology this term belongs to: AI trial matching & clinical decision support.
Shares Stratified randomisation, allocation concealment and minimisation, Ethics review (IRB, research ethics committee), Pragmatic trial, Informed consent.
Shares Futility analysis (stopped for futility), Ethics review (IRB, research ethics committee), Trial protocol and statistical analysis plan, Trial lifecycle: from protocol to label.
Shares Ethics review (IRB, research ethics committee), Trial protocol and statistical analysis plan, Trial lifecycle: from protocol to label, AI trial matching & clinical decision support.
Shares Decentralised trial, Pragmatic trial, Informed consent.
Shares Decentralised trial, Stratified randomisation, allocation concealment and minimisation, Ethics review (IRB, research ethics committee), Trial protocol and statistical analysis plan.
Shares Decentralised and hybrid clinical trials, Community oncology and site networks, AI trial matching & clinical decision support.
Shares Ethics review (IRB, research ethics committee), Informed consent, Trial lifecycle: from protocol to label.
Shares Ethics review (IRB, research ethics committee), Pragmatic trial, Informed consent.