{"entity":{"id":"accrual","kind":"term","name":"Accrual and enrolment","aka":["accrual","accrued","accruing","enrolment","enrollment","enrolling","enrolled","fully enrolled","completed enrolment","enrolment completed","recruitment","recruiting","recruited","actively recruiting","slow accrual","poor accrual","closed to accrual","open to accrual","target enrolment","trial participation","participation rate","eligibility criteria","inclusion criteria","exclusion criteria","eligible patients"],"tldr":"How many patients a trial has signed up, and how fast. Slow accrual is the commonest reason trials take years longer than planned or close without an answer; only about 5-8% of adult cancer patients ever join a trial.","summary":"Accrual depends on the number of eligible patients (narrow eligibility criteria excluding older patients, brain metastases, poor performance status or prior therapies), site activation speed, competing trials, patient awareness and travel burden, with large inequities by race, geography and income. Remedies include broader eligibility (ASCO/Friends of Cancer Research recommendations), decentralised and hybrid trials, community oncology site networks, AI trial matching, and paying for travel. Rare cancers and paediatric trials often need international consortia and a decade to accrue; 'closed to accrual' means the target number was reached and follow-up continues.","asOf":"2026-09-09","wikipedia":"https://en.wikipedia.org/wiki/Clinical_trial#Participants","links":[{"label":"Wikipedia","url":"https://en.wikipedia.org/wiki/Clinical_trial#Participants"}],"tags":[],"related":["futility","performance-status","cancer-health-disparities","rare-cancers","informed-consent","decentralised-trial","pragmatic-trial","ethics-review","trial-lifecycle","stratified-randomisation"],"cancers":[],"sections":["drug-discovery"],"technologies":["ai-trial-matching","decentralised-clinical-trials","community-oncology-networks"],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":["add-aspirin","pediatric-match"],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"category":"Trials"},"route":"/terms/accrual/","neighbours":{"term":[{"id":"cancer-health-disparities","kind":"term","name":"Cancer health disparities and equity","route":"/terms/cancer-health-disparities/"},{"id":"decentralised-trial","kind":"term","name":"Decentralised trial","route":"/terms/decentralised-trial/"},{"id":"ethics-review","kind":"term","name":"Ethics review (IRB, research ethics committee)","route":"/terms/ethics-review/"},{"id":"futility","kind":"term","name":"Futility analysis (stopped for futility)","route":"/terms/futility/"},{"id":"informed-consent","kind":"term","name":"Informed consent","route":"/terms/informed-consent/"},{"id":"performance-status","kind":"term","name":"Performance status (ECOG, Karnofsky)","route":"/terms/performance-status/"},{"id":"pragmatic-trial","kind":"term","name":"Pragmatic trial","route":"/terms/pragmatic-trial/"},{"id":"rare-cancers","kind":"term","name":"Rare cancers","route":"/terms/rare-cancers/"},{"id":"stratified-randomisation","kind":"term","name":"Stratified randomisation, allocation concealment and minimisation","route":"/terms/stratified-randomisation/"},{"id":"trial-lifecycle","kind":"term","name":"Trial lifecycle: from protocol to label","route":"/terms/trial-lifecycle/"},{"id":"trial-protocol","kind":"term","name":"Trial protocol and statistical analysis plan","route":"/terms/trial-protocol/"}],"section":[{"id":"drug-discovery","kind":"section","name":"Drug Discovery Platforms","route":"/fronts/drug-discovery/"}],"technology":[{"id":"ai-trial-matching","kind":"technology","name":"AI trial matching & clinical decision support","route":"/technologies/ai-trial-matching/"},{"id":"community-oncology-networks","kind":"technology","name":"Community oncology and site networks","route":"/technologies/community-oncology-networks/"},{"id":"decentralised-clinical-trials","kind":"technology","name":"Decentralised and hybrid clinical trials","route":"/technologies/decentralised-clinical-trials/"}],"trial":[{"id":"add-aspirin","kind":"trial","name":"Add-Aspirin","route":"/trials/add-aspirin/"},{"id":"pediatric-match","kind":"trial","name":"NCI-COG Pediatric MATCH (APEC1621)","route":"/trials/pediatric-match/"}]}}