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PAX8 (Paired box protein Pax-8) is a protein that switches other genes on and off. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Thyroid cancer.
Transcription factor for the thyroid-specific expression of the genes exclusively expressed in the thyroid cell type, maintaining the functional differentiation of such cells.
CIViC holds 1 clinical evidence item and 0 assertions across 1 variant. Open Targets scores its association with cancer at 0.71 (direct and indirect evidence; datatypes affected pathway 0.37, literature 0.99, genetic association 0.50, somatic mutation 0.95, animal model 0.53).
In plain words · PAX8 (Paired box protein Pax-8) is a protein that switches other genes on and off. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Thyroid cancer.
PAX8 (Paired box protein Pax-8) is a protein that switches other genes on and off. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Thyroid cancer.
Transcription factor for the thyroid-specific expression of the genes exclusively expressed in the thyroid cell type, maintaining the functional differentiation of such cells. Location: Nucleus (UniProt).
No product in this corpus aims at PAX8 yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
Specificity not established: no corpus medicine is aimed at it and the catalogues give it only the role biomarker; HPA finds the RNA group enriched, which says where the protein sits but not whether the tumour differs from normal tissue. HPA PAX8: RNA group enriched (kidney 241 nTPM, thyroid gland 537 nTPM); high antibody staining in 4 normal tissues; highest cancer staining thyroid cancer (2 of 4 high). Distribution: 1 cancer family in the corpus carries a prevalence row, label threshold or catalogue link for it (Thyroid cancer); Open Targets associates it with 0 specific cancer types at or above 0.5. (No rule of scripts/fetch-target-specificity.ts fired.)
Sources: Human Protein Atlas PAX8 tissue; Open Targets ENSG00000125618 associations
First described 1992. Earliest sequence paper UniProt cites for the protein: Poleev et al, Development, 1992, "PAX8, a human paired box gene: isolation and expression in developing thyroid, kidney and Wilms' tumors". Source.
Sources: HGNC HGNC:8622 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q06710 (protein name, function text, keywords and locations (REST API)); CIViC gene PAX8 (1 evidence items, 0 assertions, 1 variants; diseases: Female Reproductive Organ Cancer (GraphQL API, CC0)); Open Targets ENSG00000125618 (association with cancer (MONDO_0004992) 0.71; per-cancer scores at or above 0.5: thyroid cancer 0.61 (GraphQL API, CC0))
Transcription factor for the thyroid-specific expression of the genes exclusively expressed in the thyroid cell type, maintaining the functional differentiation of such cells. Location: Nucleus (UniProt). Locus 2q14.1 (HGNC).
RNA: group enriched (kidney 241 nTPM, thyroid gland 537 nTPM), detected in many normal tissues.
Medium: Adrenal gland, Cervix, Seminal vesicle.
RNA cancer enhanced: Thyroid Carcinoma 344 pTPM.
Medium only: cervical cancer, endometrial cancer, liver cancer.
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"PAX8" OR ABSTRACT:"PAX8" OR TITLE:"paired box 8" OR ABSTRACT:"paired box 8" OR TITLE:"Paired box protein Pax-8" OR ABSTRACT:"Paired box protein Pax-8" OR TITLE:"PAX-8" OR ABSTRACT:"PAX-8") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about PAX8, not a curated reading list.
Shares Thyroid cancer, CIViC.
Shares Thyroid cancer, Open Targets Platform.
Shares Thyroid cancer, Open Targets Platform.
Shares Thyroid cancer, Open Targets Platform.
Shares Thyroid cancer, Open Targets Platform.
Shares Thyroid cancer, Open Targets Platform.
Shares Thyroid cancer, Open Targets Platform.
Shares Thyroid cancer, Open Targets Platform.