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ATXN7 (Ataxin-7) is a protein that switches other genes on and off. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Thyroid cancer.
Acts as a component of the SAGA (aka STAGA) transcription coactivator-HAT complex. Mediates the interaction of SAGA complex with the CRX and is involved in CRX-dependent gene activation. Probably involved in tethering the deubiquitination module within the SAGA complex.
CIViC holds 4 clinical evidence items and 0 assertions across 5 variants.
In plain words · ATXN7 (Ataxin-7) is a protein that switches other genes on and off. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Thyroid cancer.
ATXN7 (Ataxin-7) is a protein that switches other genes on and off. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Thyroid cancer.
Acts as a component of the SAGA (aka STAGA) transcription coactivator-HAT complex. Mediates the interaction of SAGA complex with the CRX and is involved in CRX-dependent gene activation.
No product in this corpus aims at ATXN7 yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
Broadly expressed or essential: HPA finds the RNA at low tissue specificity; a medicine acting on the wild-type protein would expose normal tissue too. HPA ATXN7: RNA low tissue specificity; no normal tissue stained high. Distribution: 1 cancer family in the corpus carries a prevalence row, label threshold or catalogue link for it (Thyroid cancer); Open Targets associates it with 0 specific cancer types at or above 0.5. (Rule 7 of scripts/fetch-target-specificity.ts.)
Sources: Human Protein Atlas ATXN7 tissue; Open Targets ENSG00000163635 associations
First described 1997. Earliest sequence paper UniProt cites for the protein: David et al, Nat. Genet, 1997, "Cloning of the SCA7 gene reveals a highly unstable CAG repeat expansion". Source.
Sources: HGNC HGNC:10560 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt O15265 (protein name, function text, keywords and locations (REST API)); CIViC gene ATXN7 (4 evidence items, 0 assertions, 5 variants; diseases: Thyroid Cancer, Thyroid Gland Carcinoma (GraphQL API, CC0))
Acts as a component of the SAGA (aka STAGA) transcription coactivator-HAT complex. Mediates the interaction of SAGA complex with the CRX and is involved in CRX-dependent gene activation. Probably involved in tethering the deubiquitination module within the SAGA complex. Necessary for microtubule cytoskeleton stabilisation. Involved in neurodegeneration. Location: Nucleus; Nucleus, nucleolus; Nucleus matrix; Cytoplasm, cytoskeleton (UniProt). Locus 3p14.1 (HGNC).
RNA: low tissue specificity, detected in all normal tissues.
No normal tissue stained high.
No cancer sample stained medium or high.
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"ATXN7" OR ABSTRACT:"ATXN7" OR TITLE:"ataxin 7" OR ABSTRACT:"ataxin 7" OR TITLE:"Ataxin-7" OR ABSTRACT:"Ataxin-7" OR TITLE:"OPCA3" OR ABSTRACT:"OPCA3" OR TITLE:"ADCAII" OR ABSTRACT:"ADCAII" OR TITLE:"SGF73" OR ABSTRACT:"SGF73") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about ATXN7, not a curated reading list.
Shares Thyroid cancer, CIViC.
Shares Thyroid cancer, CIViC.
Shares Thyroid cancer, CIViC.
Shares Thyroid cancer, CIViC.
Shares Thyroid cancer, CIViC.
Shares Thyroid cancer, CIViC.
Shares Thyroid cancer, CIViC.
Shares Thyroid cancer, CIViC.