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EIF1AX (Eukaryotic translation initiation factor 1A, X-chromosomal) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, a tumour suppressor and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Endometrial cancer, Lung cancer, Prostate cancer and 4 more.
Component of the 43S pre-initiation complex (43S PIC), which binds to the mRNA cap-proximal region, scans mRNA 5'-untranslated region, and locates the initiation codon. This protein enhances formation of the cap-proximal complex. Together with EIF1, facilitates scanning, start codon recognition, promotion of the assembly of 48S complex at the initiation codon (43S PIC becomes 48S PIC after the start codon is reached), and dissociation of aberrant complexes.
CIViC holds 1 clinical evidence item and 0 assertions across 1 variant. Open Targets scores its association with cancer at 0.58 (direct and indirect evidence; datatypes literature 0.81, genetic association 0.00, somatic mutation 0.74). IntOGen calls it a driver in 7 cohorts (5 activating, 2 loss-of-function), covering Lung, Prostate Adenocarcinoma, Cutaneous Melanoma, Endometrial Carcinoma, Uveal Melanoma, Well-Differentiated Thyroid Cancer.
In plain words · EIF1AX (Eukaryotic translation initiation factor 1A, X-chromosomal) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, a tumour suppressor and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Endometrial cancer, Lung cancer, Prostate cancer and 4 more.
EIF1AX (Eukaryotic translation initiation factor 1A, X-chromosomal) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, a tumour suppressor and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Endometrial cancer, Lung cancer, Prostate cancer and 4 more.
Component of the 43S pre-initiation complex (43S PIC), which binds to the mRNA cap-proximal region, scans mRNA 5'-untranslated region, and locates the initiation codon. This protein enhances formation of the cap-proximal complex.
No product in this corpus aims at EIF1AX yet. Drugs fit a pocket that exists only in one shape of the mutant protein and hold it there, off.
Tumour-specific alteration: the catalogues call it an oncogene driver (IntOGen cohort analysis finds it activated more often than chance) and a tumour suppressor (IntOGen finds it knocked out more often than chance), so the direction differs between cohorts but the alteration is somatic either way; what a medicine would aim at or exploit is the altered form or its loss, absent from normal cells; no corpus medicine is aimed at it yet. HPA EIF1AX: RNA low tissue specificity; no normal tissue stained high; highest cancer staining testis cancer (5 of 12 high). Distribution: 5 cancer families in the corpus carry a prevalence row, label threshold or catalogue link for it (Endometrial cancer, Lung cancer (all types), Prostate cancer, Thyroid cancer, Skin cancer (all types)); Open Targets associates it with 0 specific cancer types at or above 0.5. (Rule 6 of scripts/fetch-target-specificity.ts.)
Sources: UniProt P47813; CIViC gene EIF1AX; IntOGen EIF1AX; Human Protein Atlas EIF1AX tissue; Open Targets ENSG00000173674 associations
First described 1994. Earliest sequence paper UniProt cites for the protein: Dever T.E. et al, J. Biol. Chem, 1994, "Determination of the amino acid sequence of rabbit, human, and wheat germ protein synthesis factor eIF-4C by cloning and chemical sequencing". Source.
Sources: HGNC HGNC:3250 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P47813 (protein name, function text, keywords and locations (REST API)); CIViC gene EIF1AX (1 evidence items, 0 assertions, 1 variants; diseases: Uveal Melanoma (GraphQL API, CC0)); Open Targets ENSG00000173674 (association with cancer (MONDO_0004992) 0.58; (GraphQL API, CC0)); IntOGen EIF1AX (driver in 7 cohorts (Act 5, LoF 2); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Component of the 43S pre-initiation complex (43S PIC), which binds to the mRNA cap-proximal region, scans mRNA 5'-untranslated region, and locates the initiation codon. This protein enhances formation of the cap-proximal complex. Together with EIF1, facilitates scanning, start codon recognition, promotion of the assembly of 48S complex at the initiation codon (43S PIC becomes 48S PIC after the start codon is reached), and dissociation of aberrant complexes. After start codon location, together with EIF5B orients the initiator methionine-tRNA in a conformation that allows 60S ribosomal subunit joining to form the 80S initiation complex. Is released after 80S initiation complex formation, just after GTP hydrolysis by EIF5B, and before release of EIF5B. Its globular part is located in the A site of the 40S ribosomal subunit. Location: Cytoplasm (UniProt). Locus Xp22.12 (HGNC).
RNA: low tissue specificity, detected in all normal tissues.
No normal tissue stained high.
Medium only: breast cancer, cervical cancer, endometrial cancer, liver cancer.
HPA EIF1AX tissue · HPA EIF1AX pathology · HPA protein class: Essential proteins
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"EIF1AX" OR ABSTRACT:"EIF1AX" OR TITLE:"eukaryotic translation initiation factor 1A X-linked" OR ABSTRACT:"eukaryotic translation initiation factor 1A X-linked" OR TITLE:"Eukaryotic translation initiation factor 1A, X-chromosomal" OR ABSTRACT:"Eukaryotic translation initiation factor 1A, X-chromosomal" OR TITLE:"eIF-1A" OR ABSTRACT:"eIF-1A" OR TITLE:"eIF-4C" OR ABSTRACT:"eIF-4C" OR TITLE:"EIF4C" OR ABSTRACT:"EIF4C") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about EIF1AX, not a curated reading list.
Shares Uveal melanoma, CIViC, IntOGen, Lung cancer (all types).
Shares Thyroid cancer, CIViC, IntOGen, Lung cancer (all types).
Shares Papillary thyroid cancer, Thyroid cancer, IntOGen, Lung cancer (all types).
Shares Thyroid cancer, Endometrial cancer, CIViC, IntOGen.
Shares Papillary thyroid cancer, Thyroid cancer, IntOGen.
Shares Papillary thyroid cancer, Thyroid cancer, IntOGen.
Shares Papillary thyroid cancer, Thyroid cancer, CIViC, IntOGen.
Shares Thyroid cancer, CIViC, Open Targets Platform, Prostate cancer.