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BACH2 (Transcription regulator protein BACH2) is a protein that switches other genes on and off. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Skin cancer and Basal cell carcinoma.
Transcriptional regulator that acts as a repressor or activator. Binds to Maf recognition elements (MARE). Plays an important role in coordinating transcription activation and repression by MAFK.
CIViC holds 2 clinical evidence items and 0 assertions across 2 variants. Open Targets scores its association with cancer at 0.58 (direct and indirect evidence; datatypes literature 0.86, animal model 0.49, genetic association 0.72).
In plain words · BACH2 (Transcription regulator protein BACH2) is a protein that switches other genes on and off. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Skin cancer and Basal cell carcinoma.
BACH2 (Transcription regulator protein BACH2) is a protein that switches other genes on and off. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Skin cancer and Basal cell carcinoma.
Transcriptional regulator that acts as a repressor or activator. Binds to Maf recognition elements (MARE).
No product in this corpus aims at BACH2 yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
Specificity not established: no corpus medicine is aimed at it and the catalogues give it only the role biomarker; HPA finds the RNA group enriched, which says where the protein sits but not whether the tumour differs from normal tissue. HPA BACH2: RNA group enriched (bone marrow 7 nTPM, lymphoid tissue 16 nTPM); high antibody staining in 3 normal tissues; highest cancer staining lymphoma (3 of 12 high). Distribution: 1 cancer family in the corpus carries a prevalence row, label threshold or catalogue link for it (Skin cancer (all types)); Open Targets associates it with 2 specific cancer types at or above 0.5 (skin cancer, basal cell carcinoma); the corpus evidence decides and the Open Targets list is quoted for comparison. (No rule of scripts/fetch-target-specificity.ts fired.)
Sources: Human Protein Atlas BACH2 tissue; Open Targets ENSG00000112182 associations
First described 2000. Earliest sequence paper UniProt cites for the protein: Sasaki et al, Oncogene, 2000, "Cloning and expression of human B cell-specific transcription factor BACH2 mapped to chromosome 6q15". Source.
Sources: HGNC HGNC:14078 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9BYV9 (protein name, function text, keywords and locations (REST API)); CIViC gene BACH2 (2 evidence items, 0 assertions, 2 variants; diseases: (GraphQL API, CC0)); Open Targets ENSG00000112182 (association with cancer (MONDO_0004992) 0.58; per-cancer scores at or above 0.5: skin cancer 0.55, basal cell carcinoma 0.53 (GraphQL API, CC0))
Transcriptional regulator that acts as a repressor or activator. Binds to Maf recognition elements (MARE). Plays an important role in coordinating transcription activation and repression by MAFK. Induces apoptosis in response to oxidative stress through repression of the antiapoptotic factor HMOX1. Positively regulates the nuclear import of actin. Is a key regulator of adaptive immunity, crucial for the maintenance of regulatory T-cell function and B-cell maturation. Location: Cytoplasm; Nucleus (UniProt). Locus 6q15 (HGNC).
RNA: group enriched (bone marrow 7 nTPM, lymphoid tissue 16 nTPM), detected in many normal tissues.
Medium: Adrenal gland, Bone marrow, Duodenum, Endometrium, Fallopian tube, Kidney, Lymph node, Nasopharynx.
Medium only: colorectal cancer, skin cancer, testis cancer, thyroid cancer.
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"BACH2" OR ABSTRACT:"BACH2" OR TITLE:"BACH transcriptional regulator 2" OR ABSTRACT:"BACH transcriptional regulator 2" OR TITLE:"Transcription regulator protein BACH2" OR ABSTRACT:"Transcription regulator protein BACH2" OR TITLE:"BTBD25" OR ABSTRACT:"BTBD25") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about BACH2, not a curated reading list.
Shares Basal cell carcinoma, Skin cancer (all types), Open Targets Platform.
Shares Basal cell carcinoma, Skin cancer (all types), Open Targets Platform.
Shares Basal cell carcinoma, Skin cancer (all types), Open Targets Platform.
Shares Basal cell carcinoma, Skin cancer (all types), Open Targets Platform.
Shares Basal cell carcinoma, Skin cancer (all types), Open Targets Platform.
Shares Basal cell carcinoma, Skin cancer (all types), Open Targets Platform.
Shares Basal cell carcinoma, Skin cancer (all types), Open Targets Platform.
Shares Basal cell carcinoma, Skin cancer (all types), Open Targets Platform.