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The liver is where bowel cancer most often spreads. Drugs delivered straight into the liver's blood supply could retrain its resident immune cells to reject arriving cancer cells.
Kupffer cells and liver sinusoidal endothelium determine whether arriving colorectal cells die or seed, and hepatic arterial infusion is an established delivery route with dedicated pumps and an experienced clinical community. Combining regional delivery with a myeloid agonist (CD40 agonist, TLR9 agonist or STING agonist) targets the niche rather than the tumour, at doses that would be intolerable systemically.
Shares Are 90% of deaths from cancer caused by metastases?, STING & innate immune agonists, Metastasis is understood least and studied last, Cold tumours and the immunosuppressive microenvironment.
Shares Are 90% of deaths from cancer caused by metastases?, Metastasis is understood least and studied last, Colorectal cancer.
Shares Are 90% of deaths from cancer caused by metastases?, Metastasis is understood least and studied last, Colorectal cancer.
Shares Are 90% of deaths from cancer caused by metastases?, Metastasis is understood least and studied last, Colorectal cancer.
Shares Are 90% of deaths from cancer caused by metastases?, Oligometastatic disease, Metastasis is understood least and studied last, Colorectal cancer.
Shares Are 90% of deaths from cancer caused by metastases?, Metastasis is understood least and studied last, Colorectal cancer.
Shares Are 90% of deaths from cancer caused by metastases?, Metastasis is understood least and studied last.
Shares Are 90% of deaths from cancer caused by metastases?, Metastasis is understood least and studied last, Colorectal cancer.