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Cancer cells in the blood wrap themselves in platelets as camouflage. Aspirin may remove that cloak, and it is cheapest to test in the patients at highest risk of relapse.
Platelet cloaking shields circulating tumour cells from natural killer cells and shear stress and supplies TGF-beta that drives epithelial-mesenchymal transition. Aspirin has adjuvant signals in PIK3CA-pathway-mutant colorectal cancer and is being tested at scale in unselected populations, but no trial has enriched for molecular residual disease, where the event rate is high and the biology is precisely platelet-tumour cell interaction.
Shares Are 90% of deaths from cancer caused by metastases?, Epithelial-mesenchymal transition & drug efflux, Metastasis is understood least and studied last, No incentive to repurpose cheap drugs.
Shares Are 90% of deaths from cancer caused by metastases?, Metastasis is understood least and studied last, Dormant cells and minimal residual disease, Liquid biopsy (ctDNA).
Shares Are 90% of deaths from cancer caused by metastases?, Metastasis is understood least and studied last, Dormant cells and minimal residual disease, MRD / molecular residual disease testing.
Shares Are 90% of deaths from cancer caused by metastases?, Metastasis is understood least and studied last, Dormant cells and minimal residual disease, MRD / molecular residual disease testing.
Shares Are 90% of deaths from cancer caused by metastases?, Metastasis is understood least and studied last, MRD / molecular residual disease testing, Colorectal cancer.
Shares Are 90% of deaths from cancer caused by metastases?, Metastasis is understood least and studied last, MRD / molecular residual disease testing, Liquid biopsy (ctDNA).
Shares CIRCULATE-Japan (GALAXY / VEGA / ALTAIR), DYNAMIC, Metastasis is understood least and studied last, Dormant cells and minimal residual disease.
Shares No incentive to repurpose cheap drugs, Dormant cells and minimal residual disease, MRD / molecular residual disease testing, Liquid biopsy (ctDNA).