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Before cancer spreads, distant organs are changed to become welcoming. A test for those changes would show which organ is at risk while a person still looks cancer-free.
Pre-metastatic niche formation involves tumour-derived exosome integrins, S100A8 and S100A9 induction, myeloid mobilisation and fibronectin deposition in the target organ. Candidate readouts exist (plasma S100A8/A9, exosomal integrin profiles, circulating LOX activity, neutrophil trajectories) but nobody has assembled them into a validated organ-specific risk assay.
Shares Are 90% of deaths from cancer caused by metastases?, Metastasis is understood least and studied last, Dormant cells and minimal residual disease, Liquid biopsy (ctDNA).
Shares Are 90% of deaths from cancer caused by metastases?, Metastasis is understood least and studied last, Dormant cells and minimal residual disease, Liquid biopsy (ctDNA).
Shares Are 90% of deaths from cancer caused by metastases?, Metastasis is understood least and studied last, Dormant cells and minimal residual disease, HR-positive / HER2-negative breast cancer.
Shares Are 90% of deaths from cancer caused by metastases?, Metastasis is understood least and studied last, HR-positive / HER2-negative breast cancer, Colorectal cancer.
Shares Are 90% of deaths from cancer caused by metastases?, Metastasis is understood least and studied last, Biomarkers are not validated or standardised, Liquid biopsy (ctDNA).
Shares Are 90% of deaths from cancer caused by metastases?, Metastasis is understood least and studied last, Biomarkers are not validated or standardised, Liquid biopsy (ctDNA).
Shares Proteomics & phosphoproteomics, Liquid biopsy (ctDNA), Colorectal cancer.
Shares Are 90% of deaths from cancer caused by metastases?, Metastasis is understood least and studied last, HR-positive / HER2-negative breast cancer, Pancreatic ductal adenocarcinoma.