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Surgery makes some immune cells throw out sticky DNA webs that trap travelling cancer cells and help them settle. Dissolving those webs during the operation might prevent some relapses.
Neutrophil extracellular traps capture circulating tumour cells and promote liver and lung seeding in multiple mouse models, and trap markers rise sharply after large cancer operations. DNase I is an approved inhaled drug and PAD4 inhibitors are in development, so a perioperative net-dissolving window trial is quick and cheap to run.
Shares Are 90% of deaths from cancer caused by metastases?, Metastasis is understood least and studied last, Dormant cells and minimal residual disease, Liquid biopsy (ctDNA).
Shares Erik Sahai, Are 90% of deaths from cancer caused by metastases?, Metastasis is understood least and studied last, Pancreatic ductal adenocarcinoma.
Shares Are 90% of deaths from cancer caused by metastases?, Metastasis is understood least and studied last, Dormant cells and minimal residual disease, MRD / molecular residual disease testing.
Shares Are 90% of deaths from cancer caused by metastases?, Metastasis is understood least and studied last, Dormant cells and minimal residual disease, MRD / molecular residual disease testing.
Shares Are 90% of deaths from cancer caused by metastases?, Metastasis is understood least and studied last, MRD / molecular residual disease testing, Colorectal cancer.
Shares Are 90% of deaths from cancer caused by metastases?, Metastasis is understood least and studied last, MRD / molecular residual disease testing, Colorectal cancer.
Shares Are 90% of deaths from cancer caused by metastases?, Metastasis is understood least and studied last, Circulating tumour DNA (ctDNA), MRD / molecular residual disease testing.
Shares Are 90% of deaths from cancer caused by metastases?, Metastasis is understood least and studied last, Circulating tumour DNA (ctDNA), MRD / molecular residual disease testing.