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Metastasis causes most cancer deaths, yet no drug is developed to stop cells spreading. Create a formal approval route for drugs that prevent metastasis, tested in people at high risk of it.
Drug development targets established tumours; anti-metastatic mechanisms (blocking dissemination, colonisation or pre-metastatic niche formation) fail in trials designed to shrink measurable disease. The proposal is a recognised metastasis-prevention indication: trials in high-risk localised disease or MRD-positive patients with distant-recurrence-free survival as the endpoint, acceptance of mechanistically anti-metastatic agents without expectation of response in bulk disease, and biomarkers of dissemination (circulating tumour cells, ctDNA) as enrichment tools, developed with regulators.
Shares Are 90% of deaths from cancer caused by metastases?, Metastasis is understood least and studied last, Minimal / molecular residual disease (MRD), MRD / molecular residual disease testing.
Shares Are 90% of deaths from cancer caused by metastases?, Metastasis is understood least and studied last, MRD / molecular residual disease testing, Colorectal cancer.
Shares Are 90% of deaths from cancer caused by metastases?, Metastasis is understood least and studied last, MRD / molecular residual disease testing, Colorectal cancer.
Shares Are 90% of deaths from cancer caused by metastases?, Metastasis is understood least and studied last, Minimal / molecular residual disease (MRD), MRD / molecular residual disease testing.
Shares Are 90% of deaths from cancer caused by metastases?, Metastasis is understood least and studied last, Colorectal cancer.
Shares Are 90% of deaths from cancer caused by metastases?, Metastasis is understood least and studied last, Colorectal cancer.
Shares Are 90% of deaths from cancer caused by metastases?, Metastasis is understood least and studied last, MRD / molecular residual disease testing, Colorectal cancer.
Shares Metastasis is understood least and studied last, Minimal / molecular residual disease (MRD), MRD / molecular residual disease testing.