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The stress of an operation may help stray cancer cells survive and settle. A few days of two cheap old drugs around surgery might reduce that risk.
Propranolol plus a COX-2 inhibitor given for days around surgery reduced pro-metastatic molecular signatures in randomised biomarker trials in breast and colorectal cancer, and observational series suggest lower recurrence. No commercial sponsor exists because both drugs are generic, so a publicly funded pragmatic trial is the only route to an answer.
Shares Are 90% of deaths from cancer caused by metastases?, Epithelial-mesenchymal transition & drug efflux, Metastasis is understood least and studied last, No incentive to repurpose cheap drugs.
Shares Metastasis is understood least and studied last, No incentive to repurpose cheap drugs, HR-positive / HER2-negative breast cancer, Colorectal cancer.
Shares Are 90% of deaths from cancer caused by metastases?, Metastasis is understood least and studied last, MRD / molecular residual disease testing, Colorectal cancer.
Shares Are 90% of deaths from cancer caused by metastases?, Metastasis is understood least and studied last, MRD / molecular residual disease testing, HR-positive / HER2-negative breast cancer.
Shares Are 90% of deaths from cancer caused by metastases?, Metastasis is understood least and studied last, HR-positive / HER2-negative breast cancer, Colorectal cancer.
Shares Are 90% of deaths from cancer caused by metastases?, Epithelial-mesenchymal transition & drug efflux, Metastasis is understood least and studied last, HR-positive / HER2-negative breast cancer.
Shares Are 90% of deaths from cancer caused by metastases?, Metastasis is understood least and studied last, MRD / molecular residual disease testing, Colorectal cancer.
Shares Are 90% of deaths from cancer caused by metastases?, Metastasis is understood least and studied last, MRD / molecular residual disease testing, HR-positive / HER2-negative breast cancer.