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Millions of tiny radioactive glass or resin beads are injected into the liver artery, lodging in the tumour and irradiating it from within.
Yttrium-90 microspheres (TheraSphere glass, SIR-Spheres resin) deliver beta radiation to hepatic tumours. Randomised trials versus sorafenib in advanced HCC (SARAH, SIRveNIB) were negative for OS but showed better tolerability and response; personalised dosimetry (DOSISPHERE-01) and radiation segmentectomy (LEGACY) established curative-intent use in early-stage disease. Standard alternative to TACE and a bridge or downstaging tool to transplant.
Arterial delivery of 20-60 µm microspheres carrying 90Y (beta emitter, 2.5 mm mean path, 64 h half-life); dose planned from 99mTc-MAA mapping and lung shunt fraction.
Query for this technology: (TITLE:"Radioembolisation" OR ABSTRACT:"Radioembolisation" OR TITLE:"TARE / SIRT, yttrium-90" OR ABSTRACT:"TARE / SIRT, yttrium-90") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Radioembolisation (TARE / SIRT, yttrium-90), not a curated reading list.
Shares Boston Scientific, Percutaneous hepatic perfusion (chemosaturation), Intermediate hepatocellular carcinoma (BCLC B), Early hepatocellular carcinoma (BCLC 0 and A).
Shares Organ tropism: seed and soil, Intermediate hepatocellular carcinoma (BCLC B), Early hepatocellular carcinoma (BCLC 0 and A), Surgery roadmap: radical operations → less surgery → no surgery when a drug has done the work.
Shares Percutaneous hepatic perfusion (chemosaturation), Small intestinal neuroendocrine tumours, Pancreatic neuroendocrine tumours, Neuroendocrine tumours.
Shares SPECT & bone scan, Dosimetry, Small intestinal neuroendocrine tumours, Pancreatic neuroendocrine tumours.
Shares Intermediate hepatocellular carcinoma (BCLC B), Early hepatocellular carcinoma (BCLC 0 and A), Advanced hepatocellular carcinoma (BCLC C).
Shares Dosimetry, Small intestinal neuroendocrine tumours, Pancreatic neuroendocrine tumours, Radioligand therapy (beta emitters).
Shares Uveal melanoma, Advanced hepatocellular carcinoma (BCLC C), Hepatocellular carcinoma, Colorectal cancer.
Shares Small intestinal neuroendocrine tumours, Pancreatic neuroendocrine tumours, Radioligand therapy (beta emitters), Neuroendocrine tumours.