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Replacing the whole diseased liver cures both the cancer and the cirrhosis underneath it, for patients whose tumours are small enough.
Mazzaferro's Milan criteria (1996: one tumour ≤5 cm or up to three ≤3 cm, no vascular invasion) yield ~70% five-year survival. Expanded criteria (UCSF, up-to-seven, AFP-adjusted) and downstaging with TACE/TARE widen eligibility; living-donor transplantation (Asan Medical Center performs the world's highest volume) relieves organ shortage. Transplantation for unresectable colorectal liver metastases (TRANSMET, 2024) and perihilar cholangiocarcinoma (Mayo protocol) is expanding.
Total hepatectomy and grafting removes the tumour and the pre-malignant cirrhotic field; immunosuppression is balanced against recurrence risk.
Query for this technology: (TITLE:"Liver transplantation for cancer" OR ABSTRACT:"Liver transplantation for cancer" OR TITLE:"Milan criteria and beyond" OR ABSTRACT:"Milan criteria and beyond") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Liver transplantation for cancer (Milan criteria and beyond), not a curated reading list.
Shares Organ tropism: seed and soil, Intermediate hepatocellular carcinoma (BCLC B), Early hepatocellular carcinoma (BCLC 0 and A), Surgery roadmap: radical operations → less surgery → no surgery when a drug has done the work.
Shares BCLC staging, Intermediate hepatocellular carcinoma (BCLC B), Early hepatocellular carcinoma (BCLC 0 and A).
Shares Immunotherapy downstaging to transplant with a safe washout, Early hepatocellular carcinoma (BCLC 0 and A), Hepatocellular carcinoma.
Shares BCLC staging, Intermediate hepatocellular carcinoma (BCLC B), Hepatocellular carcinoma.
Shares BCLC staging, Intermediate hepatocellular carcinoma (BCLC B), Early hepatocellular carcinoma (BCLC 0 and A), Surgery roadmap: radical operations → less surgery → no surgery when a drug has done the work.
Shares Extrahepatic cholangiocarcinoma (perihilar and distal), Intrahepatic cholangiocarcinoma, Biliary tract cancer (cholangiocarcinoma).
Shares Extrahepatic cholangiocarcinoma (perihilar and distal), Intrahepatic cholangiocarcinoma, Biliary tract cancer (cholangiocarcinoma).
Shares Extrahepatic cholangiocarcinoma (perihilar and distal), Intrahepatic cholangiocarcinoma, Biliary tract cancer (cholangiocarcinoma).