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Breathing in an immune-activating drug could turn the lungs into bad soil for cancer seeds, at doses far too low to cause body-wide side-effects.
Inhaled GM-CSF was tested in paediatric osteosarcoma lung metastases and inhaled interleukin-2 in renal cancer, both with local immune activation, acceptable safety and underpowered efficacy. Modern versions (an inhaled interleukin-15 superagonist, an inhaled STING agonist or an inhaled anti-CD47) could be aimed at lung-metastasis prevention rather than treatment, where the target cell burden is tiny.
Shares Are 90% of deaths from cancer caused by metastases?, STING & innate immune agonists, Metastasis is understood least and studied last, Cold tumours and the immunosuppressive microenvironment.
Shares STING & innate immune agonists, CD47, Cytokines & engineered cytokines, Cold tumours and the immunosuppressive microenvironment.
Shares Cytokines & engineered cytokines, Cold tumours and the immunosuppressive microenvironment, Renal cell carcinoma, Sarcomas (soft tissue, bone, GIST).
Shares Are 90% of deaths from cancer caused by metastases?, Metastasis is understood least and studied last.
Shares Are 90% of deaths from cancer caused by metastases?, Metastasis is understood least and studied last.
Shares Are 90% of deaths from cancer caused by metastases?, Metastasis is understood least and studied last.
Shares Are 90% of deaths from cancer caused by metastases?, Metastasis is understood least and studied last.
Shares STING & innate immune agonists, Cold tumours and the immunosuppressive microenvironment, Sarcomas (soft tissue, bone, GIST).