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Antibody manufacturing means growing antibody drugs like pembrolizumab or trastuzumab in vats of engineered hamster cells, then purifying them. It is the industrial base for most modern cancer drugs.
Chinese hamster ovary (CHO) cell lines in 2,000-20,000 L stainless or single-use bioreactors produce grams per litre of antibody, purified by Protein A chromatography and viral clearance steps. Capacity is held by pharma (Roche, Amgen, Lilly) and CDMOs (Samsung Biologics, Lonza, WuXi Biologics, Fujifilm Diosynth, Boehringer Ingelheim). Continuous processing, higher titres, and biosimilar competition are reducing cost of goods; ADC antibodies and bispecifics add engineering constraints.
Stable transfected CHO clones expressing the antibody are grown in fed-batch or perfusion culture; downstream capture, polishing, viral inactivation and filtration, formulation and fill.
Nothing recorded yet: a foundation, or a gap to fill.
Dependencies are what this technology cannot be delivered without: manufacturing steps, instruments, software, upstream methods. See its full chain on the map.
Query for this technology: (TITLE:"Antibody manufacturing" OR ABSTRACT:"Antibody manufacturing" OR TITLE:"CHO bioprocessing" OR ABSTRACT:"CHO bioprocessing") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Antibody manufacturing (CHO bioprocessing), not a curated reading list.
Shares Lonza, ADC bioconjugation manufacturing (CDMOs), The ADC supply chain (antibody, payload-linker, conjugation, fill) and the tag supporting.
Shares Single-use bioprocessing systems, Sterile fill-finish and lyophilisation, Downstream purification (Protein A capture, viral clearance, polishing) and the tag supporting.
Shares Sterile fill-finish and lyophilisation, GMP, inspections, Form 483s and warning letters and the tag supporting.
Shares ADC bioconjugation manufacturing (CDMOs), The ADC supply chain (antibody, payload-linker, conjugation, fill) and the tag supporting.
Shares ADC bioconjugation manufacturing (CDMOs), The ADC supply chain (antibody, payload-linker, conjugation, fill) and the tag supporting.
Shares Single-use bioprocessing systems, Downstream purification (Protein A capture, viral clearance, polishing) and the tag supporting.
Shares ADC bioconjugation manufacturing (CDMOs), The ADC supply chain (antibody, payload-linker, conjugation, fill) and the tag supporting.
Shares Single-use bioprocessing systems, Lonza and the tag supporting.