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Sterile fill-finish is putting the finished drug into vials under sterile conditions. It is a frequent cause of shortages when capacity is tight.
Fill-finish capacity for biologics, ADCs, and radiopharmaceutical kits is concentrated (Catalent, Vetter, Baxter BioPharma Solutions, Thermo Fisher, Lonza, Samsung Biologics); lyophilisation is common for ADCs and mRNA products. Shortages of cisplatin and carboplatin in 2023 traced to a single sterile injectables plant (Intas/Accord) failing inspection, exposing the fragility of generic oncology supply.
Fill-finish relies on aseptic filling in isolators, lyophilisation cycles tuned to product stability, and 100% container-closure integrity inspection.
Nothing recorded yet: a foundation, or a gap to fill.
Dependencies are what this technology cannot be delivered without: manufacturing steps, instruments, software, upstream methods. See its full chain on the map.
Query for this technology: (TITLE:"Sterile fill-finish and lyophilisation" OR ABSTRACT:"Sterile fill-finish and lyophilisation") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Sterile fill-finish and lyophilisation, not a curated reading list.
Shares Samsung Biologics, CDMO (contract development and manufacturing organisation), Lonza, Antibody manufacturing (CHO bioprocessing) and the tag supporting.
Shares Catalent (Novo Holdings), CDMO (contract development and manufacturing organisation), Thermo Fisher Scientific, Lonza and the tag supporting.
Shares Antibody manufacturing (CHO bioprocessing), Downstream purification (Protein A capture, viral clearance, polishing) and the tag supporting.
Shares Antibody manufacturing (CHO bioprocessing), Downstream purification (Protein A capture, viral clearance, polishing) and the tag supporting.
Shares Generic oncology drug supply and shortage mitigation, Generic sterile injectables (the 2023 platinum shortage) and the tag supporting.
Shares Lonza, The ADC supply chain (antibody, payload-linker, conjugation, fill), Antibody-drug conjugate (ADC) and the tag supporting.
Shares Generic oncology drug supply and shortage mitigation, Generic sterile injectables (the 2023 platinum shortage) and the tag supporting.
Shares CDMO (contract development and manufacturing organisation) and the tag supporting.