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Payload-linker synthesis makes the cytotoxic small molecules inside ADCs (exatecan, MMAE, DM1, PBD dimers), whose occupational exposure limits sit in the nanogram range, in facilities built so a speck of dust cannot harm a worker. A handful of licensed sites such as Lonza and WuXi STA supply them, and their lead times gate hundreds of ADCs in development.
Camptothecin derivatives (exatecan, DXd), auristatins (MMAE/MMAF), maytansinoids (DM1/DM4), and PBD dimers are synthesised under OEB 5/6 containment by specialists (Lonza, MilliporeSigma, WuXi STA, Piramal, Sterling, Ajinomoto Bio-Pharma, Levena, Cerbios, Kelun in-house) and sold as ready-to-conjugate linker-payloads. Supply is a gating factor for the hundreds of ADCs in development.
Multi-step synthesis and purification of cytotoxic small molecules and linkers under engineered containment, with occupational exposure limits in the nanogram range.
Nothing recorded yet: a foundation, or a gap to fill.
Dependencies are what this technology cannot be delivered without: manufacturing steps, instruments, software, upstream methods. See its full chain on the map.
Query for this technology: (TITLE:"Payload-linker synthesis" OR ABSTRACT:"Payload-linker synthesis" OR TITLE:"high-potency API" OR ABSTRACT:"high-potency API") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Payload-linker synthesis (high-potency API), not a curated reading list.
Shares ADC bioconjugation manufacturing (CDMOs), The ADC supply chain (antibody, payload-linker, conjugation, fill) and the tag supporting.
Shares ADC bioconjugation manufacturing (CDMOs), The ADC supply chain (antibody, payload-linker, conjugation, fill) and the tag supporting.
Shares Lonza, ADC bioconjugation manufacturing (CDMOs), The ADC supply chain (antibody, payload-linker, conjugation, fill) and the tag supporting.
Shares Lonza, The ADC supply chain (antibody, payload-linker, conjugation, fill), Antibody-drug conjugate (ADC) and the tag supporting.
Shares Small-molecule API synthesis and the tag supporting.
Shares Lonza and the tag supporting.
Shares Lonza and the tag supporting.
Shares Small-molecule API synthesis and the tag supporting.