Loading
Androgen deprivation lowers testosterone or blocks its receptor, and has been the foundation of prostate cancer treatment since 1941 (Nobel Prize 1966).
GnRH agonists/antagonists (leuprolide, relugolix) plus AR pathway inhibitors (abiraterone, enzalutamide, apalutamide, darolutamide) as triplet or doublet therapy in metastatic hormone-sensitive disease. Combined with PARP inhibitors in HRR-mutant, with capivasertib in PTEN-deficient (2026), and with 177Lu-PSMA in castration-resistant disease.
Suppress ligand or block AR; resistance via AR amplification, splice variants, and lineage plasticity.
Abiraterone is a pill that shuts down testosterone production everywhere, including inside the tumour. Discovered at the Institute of Cancer Research, now generic and used from the first metastatic diagnosis.
An AR blocker approved for prostate cancer that has spread and for high-risk disease before it shows on scans.
The old antiandrogen pill used to block the testosterone flare from GnRH agonists and in combined androgen blockade; superseded by enzalutamide-class drugs.
Darolutamide is an AR blocker that barely enters the brain, so it causes fewer falls and cognitive side effects; it is approved with and without chemotherapy.
An injectable hormone blocker for prostate cancer that lowers testosterone within days without the initial surge caused by agonists.
Enzalutamide is a second-generation androgen-receptor blocker that stops the receptor binding testosterone, entering the nucleus and switching on genes. It is approved at every stage of advanced prostate cancer, from rising PSA after surgery to castration-resistant disease, and fatigue, falls and memory problems are its main drawbacks.
Flutamide was the first tablet to block testosterone at the prostate cancer cell. It is taken with an injection that stops testosterone production, but newer drugs have largely replaced it.
Leuprolide is the injectable that shuts off testosterone production, the foundation of hormone therapy for prostate cancer since the 1980s; it is also used for ovarian suppression in premenopausal breast cancer.
Nilutamide (Nilandron) is an older antiandrogen tablet started on the day of surgical castration for metastatic prostate cancer; it is rarely used now because of lung and eye side effects.
Relugolix is the first hormone-suppressing pill for prostate cancer, working within days and wearing off quickly when stopped.
Triptorelin (Trelstar) is a one-, three- or six-monthly injection that switches off testosterone production for men with advanced prostate cancer.
Query for this technology: (TITLE:"androgen deprivation therapy" OR ABSTRACT:"androgen deprivation therapy" OR TITLE:"androgen receptor pathway inhibitor" OR ABSTRACT:"androgen receptor pathway inhibitor" OR TITLE:"enzalutamide" OR ABSTRACT:"enzalutamide" OR TITLE:"abiraterone" OR ABSTRACT:"abiraterone"). Results are unfiltered search hits about Androgen deprivation & AR pathway inhibitors, not a curated reading list.
Shares A Study of Apalutamide (ARN-509) in Men With Non-Metastatic Castration-Resistant Prostate Cancer, ARANOTE, ARAMIS, PROSPER.
Shares ELM-PC 4, COU-AA-302, COU-AA-301, PREVAIL.
Shares GETUG-AFU 15, STAMPEDE's arms, and what each one answered, LATITUDE, KEYNOTE-991.
Shares Study of SX-682 Plus Enzalutamide in Men With ARPI-Resistant Metastatic Castration Resistant Prostate Cancer, A Phase 1b/2a Study of Pocenbrodib as Monotherapy and in Combination With Darolutamide in Participants With mCRPC, A Multicenter, Randomized, Double-Blind, Placebo-Controlled Phase III Study of Fuzuloparib Combined With Abiraterone Acetate and Prednisone (AA-P) Ver, Study of XNW5004 Tablet in Combination With Enzalutamide in Subjects With Metastatic Castration-Resistant Prostate Cancer.
Shares Christopher J. Sweeney, GETUG-AFU 15, SWOG 9346 (intermittent androgen deprivation), ARASENS.
Shares Study to Continue Treatment With Darolutamide in Patients Who Have Been Participating in Previous Darolutamide Studies Supported by Bayer, A Study to Compare Darolutamide Given With Androgen Deprivation Therapy (ADT) and Placebo Given With ADT in Men With Hormone Sensitive Prostate Cancer, A Study to Learn How Well a Combination of Darolutamide and Androgen Deprivation Therapy (ADT) Works as a Treatment Before Surgery for Men Who Have Hi, ARANOTE.
Shares ELM-PC 4, HERO, COU-AA-302, ERA 223.
Shares An Efficacy and Safety Study of Enzalutamide Plus Androgen Deprivation Therapy (ADT) Versus Placebo Plus ADT in Chinese Patients With Metastatic Hormo, A Study for Subjects With Prostate Cancer Who Previously Participated in an Enzalutamide Clinical Study, Study of Talazoparib With Enzalutamide in Men With DDR Gene Mutated mCSPC, PROSPER.