Loading
Nilutamide (Nilandron) is an older antiandrogen tablet started on the day of surgical castration for metastatic prostate cancer; it is rarely used now because of lung and eye side effects.
Nilutamide was approved in 1996 for metastatic (stage D2) prostate cancer in combination with surgical castration, with treatment beginning on the day of or the day after orchiectomy, on a randomised trial in which the combination modestly delayed progression compared with castration alone. It has been superseded by bicalutamide and the second-generation antiandrogens. Interstitial pneumonitis (about 2% of patients, more in Japanese men) carries a boxed warning; delayed dark adaptation, alcohol intolerance and hepatitis are also characteristic.
Competitive androgen receptor antagonist without oestrogenic, progestational or glucocorticoid activity. Connects to Androgen receptor.
1.Nilutamide acts on Androgen receptor, the hormone receptor or the enzyme that makes the hormone.
Background: ADC sequencing, Antigen escape (antigen loss, lineage switch), BCG-unresponsive, Castration-resistant prostate cancer (CRPC), Circulating tumour DNA (ctDNA). Also on OnCo: Resistance: how tumours escape each drug class · Lines of therapy.
| Region | Year | Indication |
|---|---|---|
| US | 1996 | Metastatic (stage D2) prostate cancer in combination with surgical castration |
Country and place are remembered in this browser only. A postcode is sent to OpenStreetMap's Nominatim service to find coordinates when you press the button; nothing else leaves your device.
Query for this drug: (TITLE:"Nilutamide" OR ABSTRACT:"Nilutamide" OR TITLE:"Nilandron" OR ABSTRACT:"Nilandron" OR TITLE:"Anandron" OR ABSTRACT:"Anandron") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Nilutamide, not a curated reading list.
Shares Hormone Therapy in Treating Patients With Rising PSA Levels Following Radiation Therapy for Prostate Cancer, Hormone Therapy With or Without Surgery or Radiation Therapy in Treating Patients With Prostate Cancer, Standard Systemic Therapy With or Without Definitive Treatment in Treating Participants With Metastatic Prostate Cancer, Androgen deprivation & AR pathway inhibitors and the tag generic.
Shares Prostate cancer and the tag generic.
Shares Hormone Therapy With or Without Surgery or Radiation Therapy in Treating Patients With Prostate Cancer, Flutamide, Androgen deprivation & AR pathway inhibitors, Prostate cancer.
Shares Prostate cancer and the tag generic.
Shares Standard Systemic Therapy With or Without Definitive Treatment in Treating Participants With Metastatic Prostate Cancer, Prostate cancer and the tag generic.
Shares Flutamide, Bicalutamide, Prostate cancer.
Shares Bicalutamide, Androgen deprivation & AR pathway inhibitors, Prostate cancer.
Shares Androgen deprivation & AR pathway inhibitors, Androgen receptor, Prostate cancer.