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Flutamide was the first tablet to block testosterone at the prostate cancer cell. It is taken with an injection that stops testosterone production, but newer drugs have largely replaced it.
Flutamide was approved in 1989 for use with LHRH agonists in stage B2 to C prostate cancer (with radiotherapy) and in stage D2 metastatic disease, introducing combined androgen blockade. Trials in the 1980s and 1990s showed at best a small survival gain over castration alone, and bicalutamide, then enzalutamide, apalutamide and darolutamide superseded it because of three-times-daily dosing, diarrhoea and a boxed warning for hepatotoxicity including fatal liver failure. It is still listed for antiandrogen flare cover at the start of LHRH agonist therapy.
Competitive antagonist of the androgen receptor; its active metabolite hydroxyflutamide blocks androgen binding and nuclear translocation in prostate cells. Connects to Androgen receptor.
1.Flutamide acts on Androgen receptor, the hormone receptor or the enzyme that makes the hormone.
| Region | Year | Indication |
|---|---|---|
| US | 1989 | Locally advanced (B2 to C) and metastatic (D2) prostate cancer in combination with an LHRH agonist |
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Query for this drug: (TITLE:"Flutamide" OR ABSTRACT:"Flutamide" OR TITLE:"Eulexin" OR ABSTRACT:"Eulexin" OR TITLE:"historic" OR ABSTRACT:"historic") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Flutamide, not a curated reading list.
Shares Flutamide, Suramin, and Hydrocortisone in Treating Patients With Prostate Cancer, Hormone Therapy in Treating Patients With Rising PSA Levels Following Radiation Therapy for Prostate Cancer, Hormone Therapy With or Without Surgery or Radiation Therapy in Treating Patients With Prostate Cancer, Standard Systemic Therapy With or Without Definitive Treatment in Treating Participants With Metastatic Prostate Cancer and the tag generic.
Shares Prostate cancer and the tag generic.
Shares Hormone Therapy in Treating Patients With Rising PSA Levels Following Radiation Therapy for Prostate Cancer, Radiation Therapy With or Without Androgen-Deprivation Therapy in Treating Patients With Prostate Cancer, Hormone Therapy With or Without Surgery or Radiation Therapy in Treating Patients With Prostate Cancer, Prostate Radiation Therapy or Short-Term Androgen Deprivation Therapy and Pelvic Lymph Node Radiation Therapy With or Without Prostate Radiation Therapy in Treating Patients With a Rising Prostate Specific Antigen (PSA) After Surgery for Prostate Cancer.
Shares Standard Systemic Therapy With or Without Definitive Treatment in Treating Participants With Metastatic Prostate Cancer, Prostate cancer and the tag generic.
Shares Prostate cancer and the tag generic.
Shares Hormone Therapy Plus Radiation Therapy With or Without Combination Chemotherapy in Treating Patients With Prostate Cancer and the tag generic.
Shares Triptorelin, Flutamide, and External-Beam Radiation Therapy or External-Beam Radiation Therapy Alone in Treating Patients With Stage II or Stage III Prostate Cancer, Radiation Therapy With or Without Androgen-Deprivation Therapy in Treating Patients With Prostate Cancer, Prostate Radiation Therapy or Short-Term Androgen Deprivation Therapy and Pelvic Lymph Node Radiation Therapy With or Without Prostate Radiation Therapy in Treating Patients With a Rising Prostate Specific Antigen (PSA) After Surgery for Prostate Cancer, Standard Systemic Therapy With or Without Definitive Treatment in Treating Participants With Metastatic Prostate Cancer.
Shares Flutamide, Suramin, and Hydrocortisone in Treating Patients With Prostate Cancer, Hormone Therapy in Treating Patients With Rising PSA Levels Following Radiation Therapy for Prostate Cancer, Radiation Therapy With or Without Androgen-Deprivation Therapy in Treating Patients With Prostate Cancer, Hormone Therapy With or Without Surgery or Radiation Therapy in Treating Patients With Prostate Cancer.