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When patients who agreed in advance die of cancer, sampling every tumour within hours reveals how the disease evolved and escaped every drug. Few hospitals can do this today.
Programmes such as PEACE (UK) and CASCADE (Australia) recruit patients in life for post-mortem multi-site sampling within six hours. The proposal is to fund a standing network with 24-hour on-call pathology, consent embedded in oncology clinics, and a common sample and data model, so that terminal clonal architecture becomes a routine, shareable dataset rather than a rarity.
Shares The Francis Crick Institute, Tumour heterogeneity and clonal evolution, Cancer Research UK, Whole-exome & whole-genome sequencing.
Shares The Francis Crick Institute, Tumour heterogeneity and clonal evolution, Cancer Research UK, Whole-exome & whole-genome sequencing.
Shares The Francis Crick Institute, Single-cell & spatial profiling, Cancer Research UK, Whole-exome & whole-genome sequencing.
Shares The Francis Crick Institute, Metastasis is understood least and studied last, Tumour heterogeneity and clonal evolution, Cancer Research UK.
Shares Metastasis is understood least and studied last, Cancer Research UK.
Shares The Francis Crick Institute, Metastasis is understood least and studied last, Cancer Research UK.
Shares Metastasis is understood least and studied last, Single-cell & spatial profiling, Whole-exome & whole-genome sequencing.