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Hospitals usually keep one piece of a removed tumour. Keeping three pieces from different parts would show how varied the tumour is, at almost no extra cost.
TRACERx showed that a single region misses subclonal drivers and under-calls copy-number heterogeneity in a large share of lung cancers. Pathology protocols could mandate three or more spatially annotated blocks (core, edge, invasive front) frozen and formalin-fixed for every resected solid tumour, with the region map stored with the specimen. The marginal cost is technician time; the payoff is a national multi-region resource attached to outcomes.
Shares The Francis Crick Institute, Tumour heterogeneity and clonal evolution, Data silos, Cancer Research UK.
Shares The Francis Crick Institute, Tumour heterogeneity and clonal evolution, Cancer Research UK, Whole-exome & whole-genome sequencing.
Shares Tumour heterogeneity and clonal evolution, Whole-exome & whole-genome sequencing, Comprehensive genomic profiling.
Shares Data silos, Whole-exome & whole-genome sequencing, Comprehensive genomic profiling.
Shares The Francis Crick Institute, Tumour heterogeneity and clonal evolution, Cancer Research UK, Whole-exome & whole-genome sequencing.
Shares The Francis Crick Institute, Data silos, Cancer Research UK, Whole-exome & whole-genome sequencing.
Shares The Francis Crick Institute, Tumour heterogeneity and clonal evolution, Cancer Research UK, Colorectal cancer.